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dc.creatorIvković, Branka
dc.creatorNikolić, Katarina
dc.creatorIlić, Bojana B.
dc.creatorŽižak, Željko
dc.creatorNovaković, Radmila
dc.creatorČudina, Olivera
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:35:45Z
dc.date.available2019-09-02T11:35:45Z
dc.date.issued2013
dc.identifier.issn0223-5234
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1977
dc.description.abstractSeries of twelve chalcone and propafenone derivatives has been synthesized and evaluated for anticancer activities against Hela, Fem-X, PC-3, MCF-7, LS174 and K562 cell lines. The 2D-QSAR and 3D-QSAR studies were performed for all compounds with cytotoxic activities against each cancer cell line. Partial least squares (PLS) regression has been applied for selection of the most relevant molecular descriptors and QSAR models building. Predictive potentials of the created 2D-QSAR and 3D-QSAR models for each cell line were compared, by use of leave-one-out cross-validation and external validation, and optimal QSAR models for each cancer cell line were selected. The QSAR studies have selected the most significant molecular descriptors and pharmacophores of the chalcone and propafenone derivatives and proposed structures of novel chalcone and propafenone derivatives with enhanced anticancer activity on the HeLa, Fem-X, PC-3, MCF-7, LS174 and K562 cells.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectPropafenone derivativesen
dc.subjectChalconesen
dc.subjectQSARen
dc.subjectAnticancer agentsen
dc.titlePhenylpropiophenone derivatives as potential anticancer agents: Synthesis, biological evaluation and quantitative structure-activity relationship studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИлић, Бојана Б.; Новаковић, Радмила; Чудина, Оливера; Жижак, Жељко; Владимиров, Соте; Ивковић, Бранка; Николић, Катарина;
dc.citation.volume63
dc.citation.spage239
dc.citation.epage255
dc.citation.other63: 239-255
dc.citation.rankM21
dc.identifier.wos000322855400025
dc.identifier.doi10.1016/j.ejmech.2013.02.013
dc.identifier.pmid23501110
dc.identifier.scopus2-s2.0-84874936148
dc.identifier.rcubconv_2890
dc.type.versionpublishedVersion


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