Urinary prostate-specific antigen: predictor of benign prostatic hyperplasia progression?

Abstract

PEJCIC TP, TULIC CD, LALIC NV, GLISIC BD, IGNJATOVIC SD, MARKOVIC BB, HADZI-DJOKK JB. Urinary prostate-specific antigen: predictor of benign prostatic hyperplasia progression? Can J Urol 2013;20(2):6707-6713. Introduction: Urinary prostate-specific antigen (uPSA) can be used as additional parameter of benign prostatic hyperplasia (BPH) progression. Materials and methods: From January 2001 to December 2011, uPSA was determined in 265 patients with benign prostate. Based on total prostate volume (TPV), the patients with benign prostate were divided in two groups: TPV lt 31 mL and TPV >= 31 mL. Additional three groups were formed upon MTOPS study criteria: non-progressive BPH group (TPV lt 31 mL, PSA lt 1.6 ng/mL, age lt 62 yrs), intermediate group (one, or two parameters {TPV, PSA, age} increased) and progressive BPH group (TPV >= 31 ml, PSA >= 1.6 ng/mL, age >= 62 yrs). Results: Average uPSA values in the groups TPV lt 31 mL and TPV 31 mL were 119.3 +/- 124.5 and 255.5 +/- 204.9 ng/mL, respectively and they were significantly different (p lt 0.0001). Average uPSA values in the non-progressive BPH group, intermediate group and progressive BPH group were 86.8 +/- 82.4 ng/mL, 166.6 +/- 164.9 ng/mL and 274.9 +/- 208.3 ng/mL, respectively and they were significantly different (p lt 0.0001). The level of uPSA correlated significantly with TPV (r = 0.32, p lt 0.0001). The cut off uPSA level of 150 ng/mL discriminates the patients with non-progressive BPH and progressive BPH with specificity of 0.83 and sensitivity of 0.67. Conclusion: The level of uPSA reflects prostatic hormonal activity and correlates with TPV, PSA and age. UPSA level >= 150 ng/mL can be used as additional predictive parameter of BPH progression.