The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats
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2013
Authors
Buha, Aleksandra
Antonijević, Biljana

Bulat, Zorica

Jaćević, Vesna

Milovanović, Vesna
Matović, Vesna

Article (Published version)

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Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indica...te triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis.
Keywords:
Thyroid-disrupting chemicals / Cadmium / Polychlorinated biphenyls / Co-exposure / RatsSource:
Toxicology Letters, 2013, 221, 2, 83-90Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
DOI: 10.1016/j.toxlet.2013.06.216
ISSN: 0378-4274
PubMed: 23792431
WoS: 000323087000002
Scopus: 2-s2.0-84880257436
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PharmacyTY - JOUR AU - Buha, Aleksandra AU - Antonijević, Biljana AU - Bulat, Zorica AU - Jaćević, Vesna AU - Milovanović, Vesna AU - Matović, Vesna PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1981 AB - Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indicate triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis. PB - Elsevier Ireland Ltd, Clare T2 - Toxicology Letters T1 - The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats VL - 221 IS - 2 SP - 83 EP - 90 DO - 10.1016/j.toxlet.2013.06.216 ER -
@article{ author = "Buha, Aleksandra and Antonijević, Biljana and Bulat, Zorica and Jaćević, Vesna and Milovanović, Vesna and Matović, Vesna", year = "2013", abstract = "Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indicate triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Toxicology Letters", title = "The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats", volume = "221", number = "2", pages = "83-90", doi = "10.1016/j.toxlet.2013.06.216" }
Buha, A., Antonijević, B., Bulat, Z., Jaćević, V., Milovanović, V.,& Matović, V.. (2013). The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats. in Toxicology Letters Elsevier Ireland Ltd, Clare., 221(2), 83-90. https://doi.org/10.1016/j.toxlet.2013.06.216
Buha A, Antonijević B, Bulat Z, Jaćević V, Milovanović V, Matović V. The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats. in Toxicology Letters. 2013;221(2):83-90. doi:10.1016/j.toxlet.2013.06.216 .
Buha, Aleksandra, Antonijević, Biljana, Bulat, Zorica, Jaćević, Vesna, Milovanović, Vesna, Matović, Vesna, "The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats" in Toxicology Letters, 221, no. 2 (2013):83-90, https://doi.org/10.1016/j.toxlet.2013.06.216 . .