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The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats

Authorized Users Only
2013
Authors
Buha, Aleksandra
Antonijević, Biljana
Bulat, Zorica
Jaćević, Vesna
Milovanović, Vesna
Matović, Vesna
Article (Published version)
Metadata
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Abstract
Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indica...te triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis.

Keywords:
Thyroid-disrupting chemicals / Cadmium / Polychlorinated biphenyls / Co-exposure / Rats
Source:
Toxicology Letters, 2013, 221, 2, 83-90
Publisher:
  • Elsevier Ireland Ltd, Clare
Funding / projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.1016/j.toxlet.2013.06.216

ISSN: 0378-4274

PubMed: 23792431

WoS: 000323087000002

Scopus: 2-s2.0-84880257436
[ Google Scholar ]
62
51
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1981
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Buha, Aleksandra
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Jaćević, Vesna
AU  - Milovanović, Vesna
AU  - Matović, Vesna
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1981
AB  - Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indicate triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats
VL  - 221
IS  - 2
SP  - 83
EP  - 90
DO  - 10.1016/j.toxlet.2013.06.216
ER  - 
@article{
author = "Buha, Aleksandra and Antonijević, Biljana and Bulat, Zorica and Jaćević, Vesna and Milovanović, Vesna and Matović, Vesna",
year = "2013",
abstract = "Endocrine-disrupting chemicals currently represent one of the major concerns and this study was aimed to investigate the effects of different doses of cadmium, widespread toxic metal, on the levels of thyroid hormones and to calculate Benchmark doses for these effects. Furthermore, the effects of co-exposure to cadmium and polychlorinated biphenyls on thyroid function were investigated. Six orally-treated groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 and 10 mg Cd/kg b.w./day, five groups were orally treated with 0.5, 1, 2, 4 and 8 mg PCBs/kgb.w./day, while nine groups of rats were orally-treated with different dose combinations of Cd and PCBs (0.6, 1.25 and 2.5 mg Cd/kgb.w. and 2,4 and 8 mg PCBs/kg b.w./day), during 28 days. Thyroid hormones were adversely affected by cadmium, with most prominent effect observed on triiodothyroxine levels indicating Cd interference with thyroid function at extrathyroidal level. Calculated Benchmark doses for Cd effects on thyroid hormones indicate triiodothyroxine as the most sensitive one that can be used as a basis for risk assessment. This study also implicates possible synergistic effects of Cd and PCBs on thyroid function as a consequence of their interference at different levels of thyroid homeostasis.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats",
volume = "221",
number = "2",
pages = "83-90",
doi = "10.1016/j.toxlet.2013.06.216"
}
Buha, A., Antonijević, B., Bulat, Z., Jaćević, V., Milovanović, V.,& Matović, V.. (2013). The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 221(2), 83-90.
https://doi.org/10.1016/j.toxlet.2013.06.216
Buha A, Antonijević B, Bulat Z, Jaćević V, Milovanović V, Matović V. The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats. in Toxicology Letters. 2013;221(2):83-90.
doi:10.1016/j.toxlet.2013.06.216 .
Buha, Aleksandra, Antonijević, Biljana, Bulat, Zorica, Jaćević, Vesna, Milovanović, Vesna, Matović, Vesna, "The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats" in Toxicology Letters, 221, no. 2 (2013):83-90,
https://doi.org/10.1016/j.toxlet.2013.06.216 . .

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