FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography

No Thumbnail
Authors
Rakić, Tijana
Jovanović, Marko
Dumić, Aleksandra
Pekić, Marina
Ribić, Sanja
Jančić-Stojanović, Biljana
Article (Published version)
Metadata
Show full item record
Abstract
This paper presents multiobjective optimization of complex mixtures separation in hydrophilic interaction liquid chromatography (HILIC). The selected model mixture consisted of five psychotropic drugs: clozapine, thioridazine, sulpiride, pheniramine and lamotrigine. Three factors related to the mobile phase composition (acetonitrile content, pH of the water phase and concentration of ammonium acetate) were optimized in order to achieve the following goals: maximal separation quality, minimal total analysis duration and robustness of an optimum. The consideration of robustness in early phases of the method development provides reliable methods with low risk for failure in validation phase. The simultaneous optimization of all goals was achieved by multiple threshold approach combined with grid point search. The identified optimal separation conditions (acetonitrile content 83%, pH of the water phase 3.5 and ammonium acetate content in water phase 14 mM) were experimentally verified.
Keywords:
Hydrophilic interaction liquid chromatography / multiple threshold optimization / robustness
Source:
Acta Chimica Slovenica, 2013, 60, 2, 411-415
Publisher:
  • Slovensko Kemijsko Drustvo, Ljubljana
Funding / projects:
  • Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)

ISSN: 1318-0207

PubMed: 23878947

WoS: 000322040900022

Scopus: 2-s2.0-84880678194
[ Google Scholar ]
6
6
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1982
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1982
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Rakić, Tijana
AU  - Jovanović, Marko
AU  - Dumić, Aleksandra
AU  - Pekić, Marina
AU  - Ribić, Sanja
AU  - Jančić-Stojanović, Biljana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1982
AB  - This paper presents multiobjective optimization of complex mixtures separation in hydrophilic interaction liquid chromatography (HILIC). The selected model mixture consisted of five psychotropic drugs: clozapine, thioridazine, sulpiride, pheniramine and lamotrigine. Three factors related to the mobile phase composition (acetonitrile content, pH of the water phase and concentration of ammonium acetate) were optimized in order to achieve the following goals: maximal separation quality, minimal total analysis duration and robustness of an optimum. The consideration of robustness in early phases of the method development provides reliable methods with low risk for failure in validation phase. The simultaneous optimization of all goals was achieved by multiple threshold approach combined with grid point search. The identified optimal separation conditions (acetonitrile content 83%, pH of the water phase 3.5 and ammonium acetate content in water phase 14 mM) were experimentally verified.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography
VL  - 60
IS  - 2
SP  - 411
EP  - 415
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1982
ER  - 
@article{
author = "Rakić, Tijana and Jovanović, Marko and Dumić, Aleksandra and Pekić, Marina and Ribić, Sanja and Jančić-Stojanović, Biljana",
year = "2013",
abstract = "This paper presents multiobjective optimization of complex mixtures separation in hydrophilic interaction liquid chromatography (HILIC). The selected model mixture consisted of five psychotropic drugs: clozapine, thioridazine, sulpiride, pheniramine and lamotrigine. Three factors related to the mobile phase composition (acetonitrile content, pH of the water phase and concentration of ammonium acetate) were optimized in order to achieve the following goals: maximal separation quality, minimal total analysis duration and robustness of an optimum. The consideration of robustness in early phases of the method development provides reliable methods with low risk for failure in validation phase. The simultaneous optimization of all goals was achieved by multiple threshold approach combined with grid point search. The identified optimal separation conditions (acetonitrile content 83%, pH of the water phase 3.5 and ammonium acetate content in water phase 14 mM) were experimentally verified.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography",
volume = "60",
number = "2",
pages = "411-415",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1982"
}
Rakić, T., Jovanović, M., Dumić, A., Pekić, M., Ribić, S.,& Jančić-Stojanović, B.. (2013). Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 60(2), 411-415.
https://hdl.handle.net/21.15107/rcub_farfar_1982
Rakić T, Jovanović M, Dumić A, Pekić M, Ribić S, Jančić-Stojanović B. Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography. in Acta Chimica Slovenica. 2013;60(2):411-415.
https://hdl.handle.net/21.15107/rcub_farfar_1982 .
Rakić, Tijana, Jovanović, Marko, Dumić, Aleksandra, Pekić, Marina, Ribić, Sanja, Jančić-Stojanović, Biljana, "Robust Optimization of Psychotropic Drug Mixture Separation in Hydrophilic Interaction Liquid Chromatography" in Acta Chimica Slovenica, 60, no. 2 (2013):411-415,
https://hdl.handle.net/21.15107/rcub_farfar_1982 .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB