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dc.creatorKolasinac, Nemanja
dc.creatorKachrimanis, Kyriakos
dc.creatorĐuriš, Jelena
dc.creatorHomšek, Irena
dc.creatorGrujić, Branka
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:36:18Z
dc.date.available2019-09-02T11:36:18Z
dc.date.issued2013
dc.identifier.issn0363-9045
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1989
dc.description.abstractSolid dispersion systems have been widely used to enhance dissolution rate and oral bioavailability of poorly water-soluble drugs. However, the formulation process development and scale-up present a number of difficulties which has greatly limited their commercial applications. In this study, solid dispersions (SDs) of desloratadine (DSL) with povidone (PVP) and crospovidone (cPVP) were prepared by spray coating technique. The process involved the spray application of 96% ethanol solution of DSL and PVP/cPVP, and subsequent deposition of the coprecipitates onto microcrystalline cellulose pellets during drying by air flow in a mini spray coater. The results from the present study demonstrated that the spray coating process is efficient in preparing SDs with enhanced drug dissolution rate and it is highly efficient in organic solvent removal. Both PVP and cPVP greatly improved drug dissolution rate by SDs, with PVP showing better solubilization capability. Very fast drug dissolution rate is achieved from SDs containing PVP regardless of differences in K grade. SD with smaller particles of cPVP have higher drug dissolution rate in comparison to the cPVP with larger particles. Results from physical state characterization indicate that DSL in SDs exist in the amorphous (high free-energy) state which is probably stabilized by PVP/cPVP. After 6-month accelerated stability study, DSL remains amorphous, while PVP and cPVP act as anti-plasticizing agents, offering efficient steric hindrance for nucleation and crystal growth.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationMinistry of Science and Technological Development, Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceDrug Development and Industrial Pharmacy
dc.subjectDesloratadineen
dc.subjectPVPen
dc.subjectsolid dispersionen
dc.subjectspray coatingen
dc.subjectamorphous stateen
dc.titleSpray coating as a powerful technique in preparation of solid dispersions with enhanced desloratadine dissolution rateen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГрујић, Бранка; Коласинац, Немања; Кацхриманис, Кyриакос; Ибрић, Светлана; Хомшек, Ирена; Ђуриш, Јелена;
dc.citation.volume39
dc.citation.issue7
dc.citation.spage1020
dc.citation.epage1027
dc.citation.other39(7): 1020-1027
dc.citation.rankM22
dc.identifier.wos000319986900011
dc.identifier.doi10.3109/03639045.2012.694890
dc.identifier.pmid22676511
dc.identifier.scopus2-s2.0-84878833041
dc.identifier.rcubconv_2861
dc.type.versionpublishedVersion


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