L-FABP can be an early marker of acute kidney injury in children
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2013
Authors
Ivanišević, IvanaPeco-Antić, Amira
Vulicević, Irena
Hercog, Đorđe
Milovanović, Vladimir
Kotur-Stevuljević, Jelena

Stefanović, Aleksandra

Kocev, Nikola
Article (Published version)

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Show full item recordAbstract
Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital st...ay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
Keywords:
L-FABP / Acute kidney injury / ChildrenSource:
Pediatric Nephrology, 2013, 28, 6, 963-969Publisher:
- Springer, New York
Funding / projects:
- Role of biomarkers in early detection of kidney injury and monitoring of therapy response in chidren (RS-175079)
DOI: 10.1007/s00467-013-2421-z
ISSN: 0931-041X
PubMed: 23407997
WoS: 000317983400017
Scopus: 2-s2.0-84880572258
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Institution/Community
PharmacyTY - JOUR AU - Ivanišević, Ivana AU - Peco-Antić, Amira AU - Vulicević, Irena AU - Hercog, Đorđe AU - Milovanović, Vladimir AU - Kotur-Stevuljević, Jelena AU - Stefanović, Aleksandra AU - Kocev, Nikola PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995 AB - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB. PB - Springer, New York T2 - Pediatric Nephrology T1 - L-FABP can be an early marker of acute kidney injury in children VL - 28 IS - 6 SP - 963 EP - 969 DO - 10.1007/s00467-013-2421-z ER -
@article{ author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola", year = "2013", abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.", publisher = "Springer, New York", journal = "Pediatric Nephrology", title = "L-FABP can be an early marker of acute kidney injury in children", volume = "28", number = "6", pages = "963-969", doi = "10.1007/s00467-013-2421-z" }
Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology Springer, New York., 28(6), 963-969. https://doi.org/10.1007/s00467-013-2421-z
Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969. doi:10.1007/s00467-013-2421-z .
Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969, https://doi.org/10.1007/s00467-013-2421-z . .