Polarographic behaviour of fleroxacin and its determination in tablets

Abstract

Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR, TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility.