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Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides
(Bentham Science Publ Ltd, Sharjah, 2014)
Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and ...
Sex Differences in Macrophage Functions in Middle-Aged Rats: Relevance of Estradiol Level and Macrophage Estrogen Receptor Expression
(Springer/Plenum Publishers, New York, 2017)
The aim of this study was to examine the influence of sex on age-related changes in phenotype and functional capacity of rat macrophages. The potential role of estradiol as a contributing factor to a sex difference in ...
Alkyl polyglucoside-based adapalene-loaded microemulsions for targeted dermal delivery: Structure, stability and comparative biopharmaceutical characterization with a conventional dosage form
(Journal of Drug Delivery Science and Technology, 2019)
Aiming to develop biocompatible microemulsions based on natural alkyl polyglucoside surfactant as prospective carriers for improved dermal delivery of adapalene, phase behavior and microstructure of pseudo-ternary oil/decyl ...
Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome
(Taylor & Francis Ltd, Abingdon, 2017)
Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a ...
Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
(Hindawi Publishing Corp, New York, 2015)
The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary ...
Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin
(Elsevier, 2019)
Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery ...
How to diagnose and manage difficult problems of calcium metabolism in sarcoidosis: an evidence-based review
(Lippincott Williams & Wilkins, Philadelphia, 2011)
Purpose of review Calcium metabolism impairments have long been recognized as a complication of sarcoidosis. For more than six decades physicians and investigators have been trying to elucidate this severe problem; ...
Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach
(Springer Heidelberg, Heidelberg, 2014)
The purpose of the study was to examine and describe adjunctive lamotrigine (LTG) pharmacokinetics in paediatric and young adult patients using a nonlinear mixed effects modelling (NONMEM) approach. The study included 53 ...
Effect of six oximes on total oxidant and antioxidant status in brain of rats intoxicated with a direct acethylcholinesterase inhibitor
(Elsevier Ireland Ltd, Clare, 2017)
Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia
(Mary Ann Liebert, Inc, New Rochelle, 2017)
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects ...