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Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Multivariate analysis methods are a set of statistical
techniques that allow multiple variables to be tested
simultaneously. This makes them ideal for studying
relationships in large complex datasets. Pharmaceutical
products ...
From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression ...
Preformulation and development of preliminary nanoemulsion carrier for patent protected compound GL-II-73
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Nanopharmaceuticals offer a good option to avoid
some of the difficulties that novel drug candidates
confront. They can be tailored to adjust their water
solubility, half-life, biodistribution, and govern the release
of ...
Anatomical characterization, chemical analyses and essential oil antimicrobial activity of Hyssopus officinalis L. (Lamiaceae)
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2022)
Introduction
Hyssopus officinalis L. (Lamiaceae) is a perennial aromatic subshrub, distributed mainly in the Mediterranean area. The aerial parts of the plant are used as a culinary and medicinal herb (Hyssopi herba) ...
Pharmaceutical and technological characteristics of barium sulphate tablets -the screening of various formulation factors
(Macedonian Pharmaceutical AssociationFaculty of Pharmacy, Ss Cyril and Methodius University in Skopje, 2022)
Introduction The study examined the development of barium sulphate tablets that do not dissolve in the digestive tract
and are used as a contrasting agent for measuring transit time through the column. The main problem ...
Functional characterization of microcrystalline cellulose obtained from the crop residues
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Crop residues (CR) are usually burned in the field,
which causes air pollution, contributes to global warming,
hinders nutrient recycling, and negatively affects soil
microbes through overheating and carbon loss. There ...
A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability ...
Digital light processing 3D printing of Hydrochlorothiazide with modified release
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Additive manufacturing also known as 3D printing
gains more attention in scientific research due to its great
advantages in simple and fast producing custom-designed
products. 3D models created with computer-aided ...
Application of the Gradient boosted tree approach for thin film classification based on disintegration time
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their ...
The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly ...