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Quantitative structure retention relationship modeling in liquid chromatography method for separation of candesartan cilexetil and its degradation products
(Elsevier Science BV, Amsterdam, 2015)
Artificial neural network (ANN) is a learning system based on a computation technique, which was employed for building of the quantitative structure-retention relationship (QSRR) model for candesartan cilexetil and its ...
The role of toxic metals and metalloids in nrf2 signaling
(MDPI AG, 2021)
Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resis-tance to oxidants, serves as one of the key defensive factors against a range of pathological processessuch as oxidative damage, ...
Bcs class iv oral drugs and absorption windows: Regional-dependent intestinal permeability of furosemide
(MDPI AG, 2020)
Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-permeability) are generally poor drug candidates, yet, ~5% of oral drugs on the market belong to this class. While solubility is often ...
Thermal properties of 3-hydroxy fatty acids and their binary mixtures as phase change energy storage materials
(John Wiley & Sons, Ltd., 2020)
In the present work, we describe the chemical synthesis of 3-HFAs as prominent derivatives of fatty acids and assess if they could be applied as phase change materials (PCM). In addition, 3-HFAs were obtained by depolymerization ...
Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.)
(Elsevier, 2019)
Sweet flag rhizome (Acorus calamus L., Araceae) exhibits various biological activities such as sedative, anticonvulsant,
immunosuppressant, antidiabetic, and anti-inflammatory. This plant is protected in Serbia, but due ...
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients
(John Wiley and Sons Inc, 2022)
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational ...
Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats
(Frontiers Media S.A., 2020)
Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim ...
A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis
(Elsevier Science Inc, 2010)
Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, ...
Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
(MDPI, 2021)
The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to ...
Insight into the formation of glimepiride nanocrystals by wet media milling
(MDPI, 2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted
by wet media milling. Di erent stabilizers were tested and the obtained nanosuspensions were
solidified by spray drying in presence of ...