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The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development / Uloga fiziološki-zasnovanog farmakokinetičkog/biofarmaceutskog modelovanja u razvoju farmaceutskih preparata
(Beograd : Savez farmaceutskih udruženja Srbije, 2021)
Computer-based (in silico) modeling & simulation tools have been embraced in different
fields of pharmaceutics for a variety of applications. Among these, physiologically-based
pharmacokinetic/biopharmaceutics modeling ...
Placenta-specific plasma miR518b is a potential biomarker for preeclampsia
(Elsevier, 2020)
Introduction: MicroRNAs have a significant role in the pathogenesis of preeclampsia. Circulating microRNAs could represent a potential biomarker for preeclampsia. The aim of this study was to evaluate plasma miR210-3p and ...
An Investigation into the Factors Governing Drug Absorption and Food Effect Prediction Based on Data Mining Methodology
(Springer International Publishing, 2020)
Drug absorption is a complex process governed by a number of interrelatedphysicochemical, biopharmaceutical, and pharmacokinetic factors. In order to explore complexrelationships among these factors, multivariate exploratory ...
In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
(Frontiers Media S.A., 2020)
Rational drug design implies usage of molecular modeling techniques such as pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to explain the activity of biomolecules, define molecular ...
Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021
(MDPI AG, 2021)
Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and ...
Comparative study of the chemical composition and biological potential of honey from different regions of Serbia
(Elsevier, 2020)
A chemical characterization and biological activity of 7 honey types (multifloral, linden, rapeseed, sunflower,
phacelia, acacia and honeydew honey) from different regions of Serbia were presented. The physicochemical
...
Biological evaluation of oil-in-water microemulsions as carriers of benzothiophene analogues for dermal applications
(MDPI AG, 2021)
During the last decade, many studies have been reported on the design and formulation of novel drug delivery systems proposed for dermal or transdermal administration. The efforts focus on the development of biocompatible ...
Nanocrystal dispersion of DK-I-56–1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance
(Elsevier B.V., 2020)
DK-I-56–1 (7‑methoxy‑2-(4‑methoxy‑d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one), a recently developed deuterated pyrazoloquinolinone, has been recognized as a lead candidate for treatment of various neuropsychiatric ...
Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex / Termičko ponašanje i biološka aktivnost [co2(cl)2 tpmc](bf4)2 kompleksa
(Engineers Society for Corrosion, 2021)
A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these ...
Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents
(MDPI, 2021)
Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative ...