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Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials
(Population Approach Group Europe (PAGE), 2019)
Introduction: Daily tenofovir has proven efficacy in preventing HIV infection in high-risk populations, when patients are compliant. However, effective preventive concentration has not been determined using HIV infection ...
Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data
(Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe, 2021)
Introduction: Cyclosporine (CyA), an immunosuppressive agent, is mandatory part of post-transplantation therapy protocols. CyA shows large interindividual and intraindividual pharmacokinetic (PK) variability, has a narrow ...
Population pharmacokinetic model of infliximab in patients with fistulising Crohn’s disease
(Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe, 2023)
Introduction: Infliximab (IFX), anti-tumour necrosis factor alpha antibody, is widely used in the treatment of inflammatory bowel diseases. Patients with Crohn’s disease may develop a more complicated form which involves ...
Modelling fatigue events in prostate cancer patients on radiotherapy
(Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe, 2023)
Introduction: The second most common form of cancer in the male population is prostate cancer. Therapeutic options include radical prostatectomy, different forms of radiotherapy, hormone treatment and chemotherapy. Radical ...