Претраживање
Приказ резултата 1-10 од 55
Optimization of dissolution method for nimesuluide tablets using response surface methodology
(Elsevier Science BV, Amsterdam, 2011)
Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks
(Elsevier Science BV, Amsterdam, 2011)
Artificial neural networks (ANNs) were applied for system understanding and prediction of drug release properties from direct compacted matrix tablets using sucrose esters (SEs) as matrix-forming agents for controlled ...
An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
(Elsevier Science BV, Amsterdam, 2007)
Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. ...
P43 Improvement of color stability in pork meat depending on dietary selenium supplementation
(European Journal of Pharmaceutical Sciences, 1994)
Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets
(Elsevier Science BV, Amsterdam, 2009)
The main objective of this study was to demonstrate the possible use of dynamic neural networks to model diclofenac sodium release from polyethylene oxide hydrophilic matrix tablets. High and low molecular weight polymers ...
The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling
(Elsevier Science BV, Amsterdam, 2009)
Monitoring valproic acid (VPA) concentrations is especially challenging due to its highly variable pharmacokinetics (PK) and complex interactions with other antiepileptic drugs. We used sparse routine therapeutic drug ...
The role of therapeutic drug monitoring in optimazing pharmacotherapy of selected antiepileptics
(Elsevier Science BV, Amsterdam, 2009)
Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach
(Elsevier Science BV, Amsterdam, 2014)
Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic ...
Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats
(Elsevier Science BV, Amsterdam, 2018)
Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drug loading capacity, stability, dispersibility in aqueous media and in vitro drug release profile, was evaluated in vivo regarding effects on ...
In vitro - in silico - in vivo drug absorption model development based on mechanistic gastrointestinal simulation and artificial neural networks: Nifedipine osmotic release tablets case study
(Elsevier Science BV, Amsterdam, 2014)
In vitro - in vivo correlations (IVIVC) are generally accepted as a valuable tool in modified release formulation development aimed at (i) quantifying the in vivo drug delivery profile and formulation related effects on ...