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Elucidation of molecular mechanisms of activity of Echinacea spp. constituents for possible treatment of COVID 19 by computer-aided methods
(International Association of Physical Chemists, 2023)
Echinacea spp. have long history of use, dating from American natives. Among ten, three species (Echinacea purpurea (L.), Echinacea pallida (Nutt.) and Echinacea angustifolia (DC.)), are the most used, alone or in mixes, ...
Study of ionization of montelukast in differently charged micellar solutions as biomembrane mimetic systems
(International Association of Physical Chemists, 2023)
Montelukast is a leukotriene receptor antagonist indicated for asthma prophylaxis in adults
as well as in pediatric patients 6 months of age and older. Because it is associated with
numerous side effects, including ...
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
(International Association of Physical Chemists, 2023)
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
Tijana Stanković1, Tanja Ilić1, Ivana Pantelić1, ...
Navigating towards improved cytotoxicity assessment in nanomedicine development: Shifting from colorimetric to fluorescence-based assays
(International Association of Physical Chemists, 2023)
It is well known that the characterization of nanomedicines can pursue different levels of complexity, both in the development stage and in the quality control process [1]. In line with physicochemical aspects, even more ...
Neuro pharmacokinetics: the secret life of - old and novel - psychopharmacological drugs
(International Association of Physical Chemists, 2023)
In the 21st century, the pace of development of new pharmacological treatments for general medical and psychiatric disorders is remarkably different. While successes for the former are frequent, new drugs for mental, ...
Virtual docking and design of novel Histone deacetylase and Rho- associated protein kinases dual inhibitors (HDAC/ROCKs)
(International Association of Physical Chemists, 2023)
Histone deacetylases (HDACs) belong to a family of epigenetic enzymes that has 18 different
isoforms and play an important role in the development and progression of various tumors.
To date, five histone deacetylase ...
Bridging science & regulation: quality by design in patient- focused formulation development
(International Association of Physical Chemists, 2023)
Patient acceptance and usability play a crucial role in achieving successful therapeutic outcomes. Consequently, there is an imperative to incorporate patient-focused formulation design into the pharmaceutical development ...
Highlight on the benefits of PBPK modeling: A link between drug properties and its in vivo performance
(International Association of Physical Chemists, 2023)
Physiologically based pharmacokinetic (PBPK) modeling or more recently also known as physiologically based biopharmaceutics modeling (PBBM) is a computer-aided (in silico) biopharmaceutical tool, designed to mechanistically ...
Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias
(International Association of Physical Chemists, 2023)
The effects of Satureja Montana (SM) on retroviruses such as HIV-1 and SARS-CoV2, have been recorded in literature. Water-soluble phenols are confered as associated with inhibition of reverse transcriptases, whilst the ...
Towards the multitarget HDAC Inhibitors for the treatment of pancreatic carcinoma by joining the drug synergy predictions and the molecular modeling
(International Association of Physical Chemists, 2023)
Pancreatic ductal adenocarcinoma (PDAC) ranks among the most formidable and deadly
types of cancer. The emergence of chemoresistance in PDAC plays a significant role in the
unfavorable survival rates, making it imperative ...