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Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease
(Oxford University Press, 2022)
Metabolic acidosis, defined as a plasma or serum bicarbonate concentration <22 mmol/L, is a frequent consequence of chronic kidney disease (CKD) and occurs in ~10-30% of patients with advanced stages of CKD. Likewise, in ...
Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
(Oxford University Press, 2022)
Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is ...
Brain dysfunction in tubular and tubulointerstitial kidney diseases
(Oxford University Press, 2022)
Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of ...
Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?
(Oxford University Press, 2022)
Kidney dysfunction can profoundly influence many organ systems, and recent evidence suggests a potential role for increased albuminuria in the development of mild cognitive impairment (MCI) or dementia. Epidemiological ...
Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients
(Oxford Univ Press, Oxford, 2013)
Background. Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized ...