Приказ основних података о документу

dc.creatorPopović, Višnja
dc.creatorHeyerick, Arne
dc.creatorPetrović, Silvana
dc.creatorVan Calenbergh, Serge
dc.creatorKaralić, Izet
dc.creatorNiketić, Marjan
dc.creatorDeforce, Dieter
dc.date.accessioned2019-09-02T11:36:33Z
dc.date.available2019-09-02T11:36:33Z
dc.date.issued2013
dc.identifier.issn1307-6167
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2000
dc.description.abstractIn the search for novel cytotoxic agents, sesquiterpenoids and phenylpropanoids have provided interesting lead compounds. From the chloroform extract of the underground parts of Laserpitium latifolium, the daucane sesquiterpenoids laserpitin and acetyldesoxodehydrolaserpitin, and the phenylpropanoids laserin and latifolon were isolated as the major compounds. Acetyldesoxodehydrolaserpitin is identified for the first time in the genus Laserpitium. Using a MTT and a sulforhodamine B (SRB) assay, the cytotoxic and antiproliferative activity of the extract and compounds laserpitin, acetyldesoxodehydrolaserpitin and laserin was tested in two closely related human breast adenocarcinoma cell lines, ie. the invasive MCF 7/6 and the non-invasive MCF 7/AZ. The IC50 values of the extract were in the range of 184.72 - 397.16 mu g/mL, with the most potent effect observed in the MTT test on the MCF 7/6 line. Among the tested compounds, acetyldesoxodehydrolaserpitin exerted a most potent, concentration-dependent effect (IC50 values of 0.60 and 0.51 mu M in the MCF 7/6 cell line, and 2.29 mu M and 31.87 mu M in the MCF 7/AZ cell line in the MTT and SRB test, respectively). The effect of laserin was more pronounced in the MTT test (IC50 of 4.57 and 2.46 mu M in the MCF 7/6 and MCF 7/AZ, respectively).en
dc.publisherACG Publications
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.relationBasileus grant (Application № 1011092) - the Erasmus Mundus Action 2 program of European Comission
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceRecords of Natural Products
dc.subjectDaucane estersen
dc.subjectphenylpropanoidsen
dc.subjectLaserpitium latifoliumen
dc.subjectcytotoxic activityen
dc.titleCytotoxic Activity of Laserpitium latifolium L. Extract and Its Daucane and Phenylpropanoid Constituentsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractКаралић, Изет; Петровић, Силвана; Ван Цаленбергх, Серге; Дефорце, Диетер; Хеyерицк, Aрне; Поповић, Вишња; Никетић, Марјан;
dc.citation.volume7
dc.citation.issue3
dc.citation.spage245
dc.citation.epage249
dc.citation.other7(3): 245-249
dc.citation.rankM22
dc.identifier.wos000319558500014
dc.identifier.scopus2-s2.0-84878465750
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/14488/Cytotoxic_Activity_of_pub_2013.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_2000
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу