Fleroxacin belongs to the third genegation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. In aqueous medium fleroxacin undergoes to complex acid-base equilibrium due to its zwitter ioninc nature and two ionizable functional groups of similar acidity. The corresponding ionization constants were determined by potentiometry and spectrophotometry. On the basis of the knowledge of distribution and spectral characteristics of ionic species of fleroxacin the spectrophotometric method for determination of fleroxacin was developed. The assay was carried out in acidic media (0.1 M HCl) at a wavelenght of 286 nm. A calibration graph was obtained for fleroxacin concentrations 2-8 μg/ml with correlation coefficient a 0.9999. The method is simple and rapid, and was successfully applied to the determination of fleroxacin in commercial tablets.
Source:
Journal de Pharmacie de Belgique, 1998, 53, 3, 242-
TY - JOUR
AU - Popović, Gordana
AU - Kapetanović, Vera
AU - Milovanović, Lj
PY - 1998
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/201
AB - Fleroxacin belongs to the third genegation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. In aqueous medium fleroxacin undergoes to complex acid-base equilibrium due to its zwitter ioninc nature and two ionizable functional groups of similar acidity. The corresponding ionization constants were determined by potentiometry and spectrophotometry. On the basis of the knowledge of distribution and spectral characteristics of ionic species of fleroxacin the spectrophotometric method for determination of fleroxacin was developed. The assay was carried out in acidic media (0.1 M HCl) at a wavelenght of 286 nm. A calibration graph was obtained for fleroxacin concentrations 2-8 μg/ml with correlation coefficient a 0.9999. The method is simple and rapid, and was successfully applied to the determination of fleroxacin in commercial tablets.
T2 - Journal de Pharmacie de Belgique
T1 - Spectrophotometric determination of fleroxacin in tablets
VL - 53
IS - 3
SP - 242
ER -
@article{
author = "Popović, Gordana and Kapetanović, Vera and Milovanović, Lj",
year = "1998",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/201",
abstract = "Fleroxacin belongs to the third genegation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. In aqueous medium fleroxacin undergoes to complex acid-base equilibrium due to its zwitter ioninc nature and two ionizable functional groups of similar acidity. The corresponding ionization constants were determined by potentiometry and spectrophotometry. On the basis of the knowledge of distribution and spectral characteristics of ionic species of fleroxacin the spectrophotometric method for determination of fleroxacin was developed. The assay was carried out in acidic media (0.1 M HCl) at a wavelenght of 286 nm. A calibration graph was obtained for fleroxacin concentrations 2-8 μg/ml with correlation coefficient a 0.9999. The method is simple and rapid, and was successfully applied to the determination of fleroxacin in commercial tablets.",
journal = "Journal de Pharmacie de Belgique",
title = "Spectrophotometric determination of fleroxacin in tablets",
volume = "53",
number = "3",
pages = "242"
}
Popović, G., Kapetanović, V.,& Milovanović, L. (1998). Spectrophotometric determination of fleroxacin in tablets.
Journal de Pharmacie de Belgique, 53(3), 242.
Popović G, Kapetanović V, Milovanović L. Spectrophotometric determination of fleroxacin in tablets. Journal de Pharmacie de Belgique. 1998;53(3):242
Popović Gordana, Kapetanović Vera, Milovanović Lj, "Spectrophotometric determination of fleroxacin in tablets" Journal de Pharmacie de Belgique, 53, no. 3 (1998):242
