Computer-aided formulation development
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This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.
Keywords:Double emulsions / Formulation / Microemulsions / Optimization / Pharmaceutical emulsions / Self-microemulsifying drug delivery systems (SMEDDS)
Source:Computer-Aided Applications in Pharmaceutical Technology, 2013, 17-29
- Elsevier Inc.