This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.
Keywords:
Double emulsions / Formulation / Microemulsions / Optimization / Pharmaceutical emulsions / Self-microemulsifying drug delivery systems (SMEDDS)
Source:
Computer-Aided Applications in Pharmaceutical Technology, 2013, 17-29
TY - CHAP
AU - Đekić, Ljiljana
AU - Vasiljević, Dragana
AU - Primorac, Marija
PY - 2013
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2020
AB - This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.
PB - Elsevier Inc.
T2 - Computer-Aided Applications in Pharmaceutical Technology
T1 - Computer-aided formulation development
SP - 17
EP - 29
DO - 10.1016/B978-1-907568-27-5.50002-0
ER -
@inbook{
author = "Đekić, Ljiljana and Vasiljević, Dragana and Primorac, Marija",
year = "2013",
abstract = "This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.",
publisher = "Elsevier Inc.",
journal = "Computer-Aided Applications in Pharmaceutical Technology",
booktitle = "Computer-aided formulation development",
pages = "17-29",
doi = "10.1016/B978-1-907568-27-5.50002-0"
}
Đekić, L., Vasiljević, D.,& Primorac, M.. (2013). Computer-aided formulation development. in Computer-Aided Applications in Pharmaceutical Technology
Elsevier Inc.., 17-29.
https://doi.org/10.1016/B978-1-907568-27-5.50002-0
Đekić L, Vasiljević D, Primorac M. Computer-aided formulation development. in Computer-Aided Applications in Pharmaceutical Technology. 2013;:17-29.
doi:10.1016/B978-1-907568-27-5.50002-0 .
Đekić, Ljiljana, Vasiljević, Dragana, Primorac, Marija, "Computer-aided formulation development" in Computer-Aided Applications in Pharmaceutical Technology (2013):17-29,
https://doi.org/10.1016/B978-1-907568-27-5.50002-0 . .
