Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation
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This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.
Ključne reči:Biowaiver / Food effects / Gastrointestinal absorption / In silico modeling / In vitro-in vivo correlation / Parameter sensitivity analysis / Virtual trials
Izvor:Computer-Aided Applications in Pharmaceutical Technology, 2013, 177-232
- Elsevier Inc.