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Karakteristike i primena hitozana u farmaceutskim/biomedicinskim preparatima

dc.creatorČalija, Bojan
dc.creatorMilić, Jela
dc.creatorKrajišnik, Danina
dc.creatorRačić, Anđelka
dc.date.accessioned2019-09-02T11:37:42Z
dc.date.available2019-09-02T11:37:42Z
dc.date.issued2013
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2047
dc.description.abstractChitosans are binary linear heteropolysaccharides derived from chitin by its partial deacetylation. Due to unique cationic nature these biopolymers have enormous potential in pharmacy and biomedicine. This potential is improved by their chemical versatility (molecular mass and degree of deacetylation) and possibility of chemical derivatisation. Numerous biological activities of chitosans such as mucoadhesivity, hemostatic, hypocholesterolemic and antimicrobial activity are based on their specific polycationic nature. Gel-forming, cross-linking and polyelectrolyte complex forming ability make chitosans suitable for design of colloidal drug delivery systems, such as dendrimers, liposomes, micelles, micro- and nanoparticles. Chitosans as well as their derivates are used in commercially available wound dressings due to their hemostatic activity and ability to stimulate cell proliferation, tissue regeneration process and mild local analgesic effect. The use of chitosans as dietary supplements has been approved in many countries since their effect on maintenance of normal blood LDL cholesterol concentrations has been confirmed. Chitosan derivatives, such as N-carboxymethyl chitosan are commonly used in cosmetics, due to their gel and film forming ability, pleasant, hydrating, softening, and protecting effect on skin. There is a special interest for use of chitosans in tissue engineering due to their ability to form biocompatible porous tridimensional gel networks, whose porosity and in vivo degradation can be controlled. Lack of registered chitosan based products is a consequence of its unsolved regulatory status. Namely, its chemical versatility may affect biodistribution, biodegradation and toxicological profiles, thus making regulatory approval of chitosans as GRAS materials quite difficult.en
dc.description.abstractHitozani su linearni, binarni heteropolisaharidi dobijeni parcijalnom deacetilacijom hitina. Kao katjonski polisaharidi prirodnog porekla imaju veliki potencijal za primenu u oblasti farmacije i biomedicine. Tome dodatno doprinosi njihova strukturna raznovrsnost u pogledu molekulske mase i stepena deacetilacije, ali i mogućnost hemijske derivatizacije. Specifična polikatjonska priroda ovih biopolimera odgovorna je za njihova brojna biološka svojstva poput mukoadhezivnosti, hemostatičnog, antimikrobnog i hipoholesterolemičnog delovanja. Zahvaljujući gelirajućim sposobnostima, mogućnosti umrežavanja i građenja reverzibilnih polielektrolitnih kompleksa sa polianjonima, hitozani se koriste za izradu koloidnih nosača lekovitih supstanci poput dendrimera, liposoma, micela, mikro- i nanočestica. Hitozani i njihovi derivati ulaze u sastav komercijalno dostupnih preparata/sredstava za zarastanje rana zahvaljujući stimulaciji proliferacije ćelija i obnavljanja tkiva, hemostatskom i blagom lokalnom analgetičkom delovanju. Upotreba hitozana kao dodatka ishrani odobrena je u mnogim zemljama, a potvrđen je njihov uticaj na održavanje normalnog nivoa serumskog LDL holesterola. Derivati hitozana, poput N-karboksimetilhitozana koriste se u kozmetičkim proizvodima jer poseduju sposobnosti geliranja i formiranja filma, stvaraju prijatan osećaj na koži, omekšavaju, vlaže i štite kožu od spoljašnjih uticaja. Posebnu pažnju hitozani privlače u oblasti tkivnog inženjerstva zahvaljujući mogućnosti obrazovanja biokompatibilnih poroznih trodimenzionalnih mreža čiju je poroznost i brzinu degradacije u in vivo uslovima moguće kontrolisati. Širu primenu hitozana trenutno ograničava nerešen regulatorni status, jer strukturna raznovrsnost hitozana ima za posledicu razlike u biodistribuciji, biodegradaciji i toksikološkim profilima, što značajno otežava dobijanje GRAS statusa.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.sourceArhiv za farmaciju
dc.subjectchitosanen
dc.subjectchitinen
dc.subjectpolycationen
dc.subjectpharmaceutical/biomedical preparationsen
dc.subjecthitozansr
dc.subjecthitinsr
dc.subjectpolikatjonsr
dc.subjectfarmaceutski/biomedicinski preparatisr
dc.titleCharacteristics and application of chitosan in pharmaceutical/biomedical preparationsen
dc.titleKarakteristike i primena hitozana u farmaceutskim/biomedicinskim preparatimasr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractЧалија, Бојан; Крајишник, Данина; Милић, Јела; Рачић, Aнђелка; Карактеристике и примена хитозана у фармацеутским/биомедицинским препаратима; Карактеристике и примена хитозана у фармацеутским/биомедицинским препаратима;
dc.citation.volume63
dc.citation.issue4
dc.citation.spage347
dc.citation.epage364
dc.citation.other63(4): 347-364
dc.citation.rankM53
dc.identifier.scopus2-s2.0-84940326200
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7444/Karakteristike_i_primena_pub_2013.pdf
dc.identifier.rcubconv_501
dc.type.versionpublishedVersion


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