Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease
Apstrakt
While Alzheimer's disease (AD) is primarily considered to be a neurodegenerative disorder, there is much evidence supporting the idea that it is also a systematic disease, so the occurrence of genomic instability in cells that are not neurons is equally important. Accordingly, acrocentric chromosomes play an important role in the etiology of AD, especially the presence of trisomy 21. The aim of this work was to assess the relationship between the frequency of acrocentrics included in satellite association (SA) and acrocentrics with premature centromere division (PCD) in the peripheral blood lymphocytes of AD patients and age-matched controls. Since our results showed that there are significant differences in SA frequency, as well as in the frequency of PCD in acrocentrics between AD patients and control group, we may conclude that the occurrence of acrocentric chromosome alterations presented in this study could be related to the etiology of AD.
Ključne reči:
Satellite association / premature centromere division / Alzheimer's diseaseIzvor:
Archives of Biological Sciences, 2013, 65, 2, 439-445Izdavač:
- Srpsko biološko društvo, Beograd, i dr.
Finansiranje / projekti:
- Aberacije ćelijskog ciklusa i uticaj oksidativnog stresa na neurodegenerativne procese i malignu transformaciju ćelije (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.2298/ABS1302439Z
ISSN: 0354-4664
WoS: 000318826000004
Scopus: 2-s2.0-84876976357
Institucija/grupa
PharmacyTY - JOUR AU - Živković, Lada AU - Bajić, Vladan AU - Žukovec, Dijana AU - Čabarkapa, Andrea AU - Potparević, Biljana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2060 AB - While Alzheimer's disease (AD) is primarily considered to be a neurodegenerative disorder, there is much evidence supporting the idea that it is also a systematic disease, so the occurrence of genomic instability in cells that are not neurons is equally important. Accordingly, acrocentric chromosomes play an important role in the etiology of AD, especially the presence of trisomy 21. The aim of this work was to assess the relationship between the frequency of acrocentrics included in satellite association (SA) and acrocentrics with premature centromere division (PCD) in the peripheral blood lymphocytes of AD patients and age-matched controls. Since our results showed that there are significant differences in SA frequency, as well as in the frequency of PCD in acrocentrics between AD patients and control group, we may conclude that the occurrence of acrocentric chromosome alterations presented in this study could be related to the etiology of AD. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease VL - 65 IS - 2 SP - 439 EP - 445 DO - 10.2298/ABS1302439Z ER -
@article{ author = "Živković, Lada and Bajić, Vladan and Žukovec, Dijana and Čabarkapa, Andrea and Potparević, Biljana", year = "2013", abstract = "While Alzheimer's disease (AD) is primarily considered to be a neurodegenerative disorder, there is much evidence supporting the idea that it is also a systematic disease, so the occurrence of genomic instability in cells that are not neurons is equally important. Accordingly, acrocentric chromosomes play an important role in the etiology of AD, especially the presence of trisomy 21. The aim of this work was to assess the relationship between the frequency of acrocentrics included in satellite association (SA) and acrocentrics with premature centromere division (PCD) in the peripheral blood lymphocytes of AD patients and age-matched controls. Since our results showed that there are significant differences in SA frequency, as well as in the frequency of PCD in acrocentrics between AD patients and control group, we may conclude that the occurrence of acrocentric chromosome alterations presented in this study could be related to the etiology of AD.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease", volume = "65", number = "2", pages = "439-445", doi = "10.2298/ABS1302439Z" }
Živković, L., Bajić, V., Žukovec, D., Čabarkapa, A.,& Potparević, B.. (2013). Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 65(2), 439-445. https://doi.org/10.2298/ABS1302439Z
Živković L, Bajić V, Žukovec D, Čabarkapa A, Potparević B. Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease. in Archives of Biological Sciences. 2013;65(2):439-445. doi:10.2298/ABS1302439Z .
Živković, Lada, Bajić, Vladan, Žukovec, Dijana, Čabarkapa, Andrea, Potparević, Biljana, "Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease" in Archives of Biological Sciences, 65, no. 2 (2013):439-445, https://doi.org/10.2298/ABS1302439Z . .