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Nanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnost

dc.creatorĐorđević, Sanela
dc.creatorCekić, Nebojša
dc.creatorIsailović, Tanja
dc.creatorMilić, Jela
dc.creatorVuleta, Gordana
dc.creatorLazić, Miodrag
dc.creatorSavić, Snežana
dc.date.accessioned2019-09-02T11:38:09Z
dc.date.available2019-09-02T11:38:09Z
dc.date.issued2013
dc.identifier.issn0367-598X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2064
dc.description.abstractThe aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80-based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40 mass% medium chain triglyceride as oil phase, and 4, 6 and 8 mass% lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The effects of emulsifier type, emulsifier concentration and oil content were investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All the produced formulations revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0.072-0.124). Zeta potentials were found to be about -20 and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained from the stability studies (6 months at 25 °C and 1 month at 40 °C) indicated that nanoemulsion stability was influenced by their composition. The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization.en
dc.description.abstractCilj ovog istraživanja bio je da se homogenizacijom pod visokim pritiskom izrade nanoemulzije stabilizovane alkil poliglukozidnim (APG) emulgatorom i da se njihove karakteristike i fizička stabilnost uporede sa nanoemulzijama stabilizovanim standardnom kombinacijom lecitina (L) i polisorbata 80 (P80). U istraživanju je praćen uticaj parametara formulacije, i to vrste i koncentracije emulgatora (smeša L/P80 vs. APG, u koncentraciji od 4, 6 i 8%) i koncentracije uljane faze (20, 30 i 40% trigliceridi srednje dužine lanca) na veličinu i raspodelu veličina kapi, zeta potencijal (ζ) i fizičku stabilnost nanoemulzija. Takođe je praćen uticaj procesnih parametara (postupak, pritisak i broj ciklusa homogenizacije) na veličinu kapi i indeks polidisperznosti (PdI), u cilju identifikovanja optimalnih uslova za izradu nanoemulzija. Dobijeni rezultati pokazuju da postoji uticaj sastava formulacije na karakteristike (L/P80 nanoemulzije: veličina kapi 147-156 nm, ζ oko -20 mV; APG nanoemulzije: veličina kapi 165-228 nm, ζ oko -50 mV) i fizičku stabilnost ispitivanih nanoemulzija, i da se diskontinualnim postupkom homogenizacije (9 ciklusa, 500 bar) mogu dobiti nanoemulzije optimalnih svojstava (veličina kapi, PdI).sr
dc.publisherSavez hemijskih inženjera, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.sourceHemijska industrija
dc.subjectNanoemulsionen
dc.subjectCaprylyl/capryl glucosideen
dc.subjectLecithinen
dc.subjectPolysorbate 80en
dc.subjectHigh pressure homogenizationen
dc.subjectPhysical stabilityen
dc.subjectnanoemulzijasr
dc.subjectkaprilil/kapril glukozidsr
dc.subjectlecitinsr
dc.subjectpolisorbat 80sr
dc.subjecthomogenizacija pod visokim pritiskomsr
dc.subjectfizička stabilnostsr
dc.titleNanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stabilityen
dc.titleNanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnostsr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЦекић, Небојша; Ђорђевић, Санела; Милић, Јела; Исаиловић, Тања; Савић, Снежана; Лазић, Миодраг; Вулета, Гордана; Наноемулзије добијене варирањем типа емулгатора и удела масне фазе - утицај формулације и процесних параметара на карактеристике и физичку стабилност; Наноемулзије добијене варирањем типа емулгатора и удела масне фазе - утицај формулације и процесних параметара на карактеристике и физичку стабилност;
dc.citation.volume67
dc.citation.issue5
dc.citation.spage795
dc.citation.epage809
dc.citation.other67(5): 795-809
dc.citation.rankM23
dc.identifier.wos000328524400011
dc.identifier.doi10.2298/HEMIND120905005D
dc.identifier.scopus2-s2.0-84888410353
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/808/2062.pdf
dc.identifier.rcubconv_927
dc.type.versionpublishedVersion


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