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dc.creatorBožić, Dragana
dc.creatorMilenković, Marina
dc.creatorIvković, Branka
dc.creatorCirković, Ivana
dc.date.accessioned2019-09-02T11:38:17Z
dc.date.available2019-09-02T11:38:17Z
dc.date.issued2014
dc.identifier.issn0971-5916
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2071
dc.description.abstractBackground & objectives: Multidrug-resistance of methicillin-resistant Staphylococcus aureus (MRSA) is a serious therapeutical problem. Chalcones belong to a group of naturally occurring flavonoids, usually found in various plant species, and have potent antibacterial, antiviral and antifungal activities. The goal of this study was to evaluate the antibacterial effect of three newly-synthesized chalcones against clinical isolates of MRSA, and their synergism with beta-lactam and non-beta-lactam antibiotics. Methods: Antimicrobial activity of the three newly-synthesized chalcones was tested against 19 clinical isolates of MRSA and a laboratory control strain of MRSA (ATCC 43300). The synergism with beta-lactams: cefotaxime (CFX), ceftriaxone (CTX), and non-beta-lactam antibiotics: ciprofloxacin (CIP), gentamicin (GEN) and trimethoprim/sulphamethoxazole (TMP-SMX) was investigated by checkerboard method. Results: All evaluated compounds showed significant anti-MRSA activity with MIC values from 25-200 g/ml. Observed synergism with antibiotics demonstrated that chalcones significantly enhanced the efficacy of CIP, GEN and TMP-SMX. Interpretation & conclusions: our study demonstrated that three newly-synthesized chalcones exhibited significant anti-MRSA effect and synergism with non-beta-lactam antibiotics. The most effective compound was 1,3-Bis-(2-hydroxy-phenyl)-propenone. Our results provide useful information for future research of possible application of chalcones in combination with conventional anti-MRSA therapy as promising new antimicrobial agents.en
dc.publisherIndian Council Medical Res, New Delhi
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175039/RS//
dc.rightsopenAccess
dc.sourceIndian Journal of Medical Research
dc.subjectChalconesen
dc.subjectcheckerboard methoden
dc.subjectMRSAen
dc.subjectmultidrug-resistanceen
dc.subjectsynergyen
dc.titleAntibacterial activity of three newly-synthesized chalcones & synergism with antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureusen
dc.typearticle
dc.rights.licenseBY-NC-SA
dcterms.abstractИвковић, Бранка; Цирковић, Ивана; Миленковић, Марина; Божић, Драгана;
dc.citation.volume140
dc.citation.spage130
dc.citation.epage137
dc.citation.other140: 130-137
dc.citation.rankM22
dc.identifier.wos000341775800020
dc.identifier.pmid25222788
dc.identifier.rcubconv_3156
dc.type.versionpublishedVersion


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