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Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains

Authorized Users Only
2014
Authors
Dimitrijević, Mirjana
Stanojević, Stanislava
Vujić, Vesna
Aleksić, Iva
Pilipović, Ivan
Leposavić, Gordana
Article (Published version)
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Abstract
Altered functions of macrophages with aging contribute to impairment of both innate and adaptive immunity in the elderly. The present study aimed to examine strain specificity of age-related changes in the phenotypic and functional characteristics of macrophages from DA and AO rats, which differ in average life span. Resident peritoneal macrophages from young (10-12 weeks old) and aged (98-104 weeks old) rats were tested for: (a) the surface expression of TLR4 and CD14; (b) the basal and LPS-induced production of TNF-alpha and IL-10; and
Keywords:
Aging / Macrophages / Cytokines / NO/urea balance / DP4 / Rat strains
Source:
Biogerontology, 2014, 15, 5, 475-486
Publisher:
  • Springer, New York
Funding / projects:
  • Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-175050)

DOI: 10.1007/s10522-014-9513-4

ISSN: 1389-5729

PubMed: 25009084

WoS: 000342080300006

Scopus: 2-s2.0-84906936202
[ Google Scholar ]
19
17
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2073
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Aleksić, Iva
AU  - Pilipović, Ivan
AU  - Leposavić, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2073
AB  - Altered functions of macrophages with aging contribute to impairment of both innate and adaptive immunity in the elderly. The present study aimed to examine strain specificity of age-related changes in the phenotypic and functional characteristics of macrophages from DA and AO rats, which differ in average life span. Resident peritoneal macrophages from young (10-12 weeks old) and aged (98-104 weeks old) rats were tested for: (a) the surface expression of TLR4 and CD14; (b) the basal and LPS-induced production of TNF-alpha and IL-10; and
PB  - Springer, New York
T2  - Biogerontology
T1  - Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains
VL  - 15
IS  - 5
SP  - 475
EP  - 486
DO  - 10.1007/s10522-014-9513-4
ER  - 
@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Aleksić, Iva and Pilipović, Ivan and Leposavić, Gordana",
year = "2014",
abstract = "Altered functions of macrophages with aging contribute to impairment of both innate and adaptive immunity in the elderly. The present study aimed to examine strain specificity of age-related changes in the phenotypic and functional characteristics of macrophages from DA and AO rats, which differ in average life span. Resident peritoneal macrophages from young (10-12 weeks old) and aged (98-104 weeks old) rats were tested for: (a) the surface expression of TLR4 and CD14; (b) the basal and LPS-induced production of TNF-alpha and IL-10; and",
publisher = "Springer, New York",
journal = "Biogerontology",
title = "Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains",
volume = "15",
number = "5",
pages = "475-486",
doi = "10.1007/s10522-014-9513-4"
}
Dimitrijević, M., Stanojević, S., Vujić, V., Aleksić, I., Pilipović, I.,& Leposavić, G.. (2014). Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains. in Biogerontology
Springer, New York., 15(5), 475-486.
https://doi.org/10.1007/s10522-014-9513-4
Dimitrijević M, Stanojević S, Vujić V, Aleksić I, Pilipović I, Leposavić G. Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains. in Biogerontology. 2014;15(5):475-486.
doi:10.1007/s10522-014-9513-4 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Aleksić, Iva, Pilipović, Ivan, Leposavić, Gordana, "Aging oppositely affects TNF-alpha and IL-10 production by macrophages from different rat strains" in Biogerontology, 15, no. 5 (2014):475-486,
https://doi.org/10.1007/s10522-014-9513-4 . .

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