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dc.creatorKeck, Cornelia M.
dc.creatorKovacević, Anđelka
dc.creatorMueller, Rainer H.
dc.creatorSavić, Snežana
dc.creatorVuleta, Gordana
dc.creatorMilić, Jela
dc.date.accessioned2019-09-02T11:38:29Z
dc.date.available2019-09-02T11:38:29Z
dc.date.issued2014
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2078
dc.description.abstractAlkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C and 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectSolid lipid nanoparticlesen
dc.subjectSLNen
dc.subjectAlkyl polyglucosidesen
dc.subjectSizeen
dc.subjectCrystallinityen
dc.subjectPhysical stabilityen
dc.titleFormulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactantsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКовацевић, Aнђелка; Милић, Јела; Муеллер, Раинер Х.; Савић, Снежана; Кецк, Цорнелиа М.; Вулета, Гордана;
dc.citation.volume474
dc.citation.issue1-2
dc.citation.spage33
dc.citation.epage41
dc.citation.other474(1-2): 33-41
dc.citation.rankM21
dc.identifier.wos000342681700005
dc.identifier.doi10.1016/j.ijpharm.2014.08.008
dc.identifier.pmid25108048
dc.identifier.scopus2-s2.0-84906079253
dc.identifier.rcubconv_3169
dc.type.versionpublishedVersion


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