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dc.creatorVemić, Ana
dc.creatorMalenović, Anđelija
dc.creatorRakić, Tijana
dc.creatorKostić, Nada
dc.creatorJančić-Stojanović, Biljana
dc.date.accessioned2019-09-02T11:38:30Z
dc.date.available2019-09-02T11:38:30Z
dc.date.issued2014
dc.identifier.issn0021-9665
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2079
dc.description.abstractCertain chemometrical tools allow an efficient way to provide valuable data to evaluate the retention behavior of analytes in liquid chromatography. In this study of the retention behavior of azole antifungals, the experimental design was applied in combination with artificial neural networks (ANNs). Three potentially significant factors (methanol content, pH of the mobile phase and column temperature) were incorporated in the plan of experiments, defined by central composite design. As the system outputs, the retention factors of all six investigated substances (fluconazole, ketoconazole, bifonazole, clotrimazole, econazole and miconazole) were determined. The pattern for the analyzed behavior of the system was created by employing ANNs. The final, optimized topology of the highly predictive network was 3-8-6. Twelve experiments were used in a training set, whereas a back-propagation algorithm was optimal for network training. The ability of the defined network to predict the retention of the investigated azoles was confirmed by correlations higher than 0.9912 for all analytes. The presented approach allowed the adequate prediction of the retention behavior of azoles, in addition to the extraction of important information for a better understanding of the analyzed system.en
dc.publisherOxford Univ Press Inc, Cary
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsopenAccess
dc.sourceJournal of Chromatographic Science
dc.titleChemometrical Tools in the Study of the Retention Behavior of Azole Antifungalsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРакић, Тијана; Јанчић-Стојановић, Биљана; Костић, Нада; Вемић, Aна; Маленовић, Aнђелија;
dc.citation.volume52
dc.citation.issue2
dc.citation.spage95
dc.citation.epage102
dc.citation.other52(2): 95-102
dc.citation.rankM23
dc.identifier.wos000342733800001
dc.identifier.doi10.1093/chromsci/bms211
dc.identifier.pmid23295779
dc.identifier.scopus2-s2.0-84892694675
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/821/2077.pdf
dc.identifier.rcubconv_3170
dc.type.versionpublishedVersion


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