Indirect Estimation of Reference Intervals for Thyroid Parameters
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2014
Authors
Milinković, Neda
Ignjatović, Svetlana

Žarković, Miloš
Radosavljević, Branimir
Majkić-Singh, Nada
Article (Published version)

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Background: The aim of this work was to determine indirect reference intervals from patients' results obtained during routine laboratory work. This could be an accurate alternative to the laborious and expensive job of producing reference intervals for populations according to international recommendations. Methods: All the results for thyrotropin (TSH), total and free thyroxine, and triiodothyronine (T4, fT4, T3, and fT3) stored in our laboratory information system between 2008 and 2011 were included in this study. We used logarithmic transformation of the raw data to exclude outliers. After visual observation of the data distribution, we estimated non-parametric reference intervals. A standard normal deviation test was performed to test the significance of differences between subgroups. Results: There was no significant difference in the serum levels of the analyzed thyroid parameters, so we calculated combined reference values. However, we found a significant difference in TSH value...s between ambulatory and hospitalized patients, but only in 2011. Indirect reference values for TSH, T4, fT4, T3 and fT3 were 0.42 - 3.67 mIU/L, 66.0 - 136.10 nmol/L, 10.20 - 18.40 pmol/L, 1.10 - 2.39 nmol/L, and 3.17 - 5.59 pmol/L, respectively. Conclusions: The indirect determination of laboratory-specific reference intervals using patients' laboratory data is a relatively easy and inexpensive method. Also, indirect reference limits will be more precise and true if skewness and kurtosis of the distribution are not too large.
Keywords:
laboratory data base / reference limits / thyroid hormonesSource:
Clinical Laboratory, 2014, 60, 7, 1083-1089Publisher:
- Clin Lab Publ, Heidelberg
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.7754/Clin.Lab.2013.130733
ISSN: 1433-6510
PubMed: 25134375
WoS: 000342857700002
Scopus: 2-s2.0-84905025874
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Institution/Community
PharmacyTY - JOUR AU - Milinković, Neda AU - Ignjatović, Svetlana AU - Žarković, Miloš AU - Radosavljević, Branimir AU - Majkić-Singh, Nada PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2081 AB - Background: The aim of this work was to determine indirect reference intervals from patients' results obtained during routine laboratory work. This could be an accurate alternative to the laborious and expensive job of producing reference intervals for populations according to international recommendations. Methods: All the results for thyrotropin (TSH), total and free thyroxine, and triiodothyronine (T4, fT4, T3, and fT3) stored in our laboratory information system between 2008 and 2011 were included in this study. We used logarithmic transformation of the raw data to exclude outliers. After visual observation of the data distribution, we estimated non-parametric reference intervals. A standard normal deviation test was performed to test the significance of differences between subgroups. Results: There was no significant difference in the serum levels of the analyzed thyroid parameters, so we calculated combined reference values. However, we found a significant difference in TSH values between ambulatory and hospitalized patients, but only in 2011. Indirect reference values for TSH, T4, fT4, T3 and fT3 were 0.42 - 3.67 mIU/L, 66.0 - 136.10 nmol/L, 10.20 - 18.40 pmol/L, 1.10 - 2.39 nmol/L, and 3.17 - 5.59 pmol/L, respectively. Conclusions: The indirect determination of laboratory-specific reference intervals using patients' laboratory data is a relatively easy and inexpensive method. Also, indirect reference limits will be more precise and true if skewness and kurtosis of the distribution are not too large. PB - Clin Lab Publ, Heidelberg T2 - Clinical Laboratory T1 - Indirect Estimation of Reference Intervals for Thyroid Parameters VL - 60 IS - 7 SP - 1083 EP - 1089 DO - 10.7754/Clin.Lab.2013.130733 ER -
@article{ author = "Milinković, Neda and Ignjatović, Svetlana and Žarković, Miloš and Radosavljević, Branimir and Majkić-Singh, Nada", year = "2014", abstract = "Background: The aim of this work was to determine indirect reference intervals from patients' results obtained during routine laboratory work. This could be an accurate alternative to the laborious and expensive job of producing reference intervals for populations according to international recommendations. Methods: All the results for thyrotropin (TSH), total and free thyroxine, and triiodothyronine (T4, fT4, T3, and fT3) stored in our laboratory information system between 2008 and 2011 were included in this study. We used logarithmic transformation of the raw data to exclude outliers. After visual observation of the data distribution, we estimated non-parametric reference intervals. A standard normal deviation test was performed to test the significance of differences between subgroups. Results: There was no significant difference in the serum levels of the analyzed thyroid parameters, so we calculated combined reference values. However, we found a significant difference in TSH values between ambulatory and hospitalized patients, but only in 2011. Indirect reference values for TSH, T4, fT4, T3 and fT3 were 0.42 - 3.67 mIU/L, 66.0 - 136.10 nmol/L, 10.20 - 18.40 pmol/L, 1.10 - 2.39 nmol/L, and 3.17 - 5.59 pmol/L, respectively. Conclusions: The indirect determination of laboratory-specific reference intervals using patients' laboratory data is a relatively easy and inexpensive method. Also, indirect reference limits will be more precise and true if skewness and kurtosis of the distribution are not too large.", publisher = "Clin Lab Publ, Heidelberg", journal = "Clinical Laboratory", title = "Indirect Estimation of Reference Intervals for Thyroid Parameters", volume = "60", number = "7", pages = "1083-1089", doi = "10.7754/Clin.Lab.2013.130733" }
Milinković, N., Ignjatović, S., Žarković, M., Radosavljević, B.,& Majkić-Singh, N.. (2014). Indirect Estimation of Reference Intervals for Thyroid Parameters. in Clinical Laboratory Clin Lab Publ, Heidelberg., 60(7), 1083-1089. https://doi.org/10.7754/Clin.Lab.2013.130733
Milinković N, Ignjatović S, Žarković M, Radosavljević B, Majkić-Singh N. Indirect Estimation of Reference Intervals for Thyroid Parameters. in Clinical Laboratory. 2014;60(7):1083-1089. doi:10.7754/Clin.Lab.2013.130733 .
Milinković, Neda, Ignjatović, Svetlana, Žarković, Miloš, Radosavljević, Branimir, Majkić-Singh, Nada, "Indirect Estimation of Reference Intervals for Thyroid Parameters" in Clinical Laboratory, 60, no. 7 (2014):1083-1089, https://doi.org/10.7754/Clin.Lab.2013.130733 . .