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dc.creatorMilinković, Neda
dc.creatorIgnjatović, Svetlana
dc.creatorŽarković, Miloš
dc.creatorRadosavljević, Branimir
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:38:32Z
dc.date.available2019-09-02T11:38:32Z
dc.date.issued2014
dc.identifier.issn1433-6510
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2081
dc.description.abstractBackground: The aim of this work was to determine indirect reference intervals from patients' results obtained during routine laboratory work. This could be an accurate alternative to the laborious and expensive job of producing reference intervals for populations according to international recommendations. Methods: All the results for thyrotropin (TSH), total and free thyroxine, and triiodothyronine (T4, fT4, T3, and fT3) stored in our laboratory information system between 2008 and 2011 were included in this study. We used logarithmic transformation of the raw data to exclude outliers. After visual observation of the data distribution, we estimated non-parametric reference intervals. A standard normal deviation test was performed to test the significance of differences between subgroups. Results: There was no significant difference in the serum levels of the analyzed thyroid parameters, so we calculated combined reference values. However, we found a significant difference in TSH values between ambulatory and hospitalized patients, but only in 2011. Indirect reference values for TSH, T4, fT4, T3 and fT3 were 0.42 - 3.67 mIU/L, 66.0 - 136.10 nmol/L, 10.20 - 18.40 pmol/L, 1.10 - 2.39 nmol/L, and 3.17 - 5.59 pmol/L, respectively. Conclusions: The indirect determination of laboratory-specific reference intervals using patients' laboratory data is a relatively easy and inexpensive method. Also, indirect reference limits will be more precise and true if skewness and kurtosis of the distribution are not too large.en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjectlaboratory data baseen
dc.subjectreference limitsen
dc.subjectthyroid hormonesen
dc.titleIndirect Estimation of Reference Intervals for Thyroid Parametersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадосављевић, Бранимир; Жарковић, Милош; Милинковић, Неда; Игњатовић, Светлана; Мајкић-Сингх, Нада;
dc.citation.volume60
dc.citation.issue7
dc.citation.spage1083
dc.citation.epage1089
dc.citation.other60(7): 1083-1089
dc.citation.rankM23
dc.identifier.wos000342857700002
dc.identifier.doi10.7754/Clin.Lab.2013.130733
dc.identifier.pmid25134375
dc.identifier.scopus2-s2.0-84905025874
dc.identifier.rcubconv_3175
dc.type.versionpublishedVersion


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