Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
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Authors
Đunić, IrenaDopsaj, Violeta

Miljić, Predrag
Savić, Nebojša
Milić, Nataša
Mitrović, Mirjana
Suvajdžić-Vuković, Nada
Tomin, Dragica
Elezović, Ivo
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Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 m...onths of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
Keywords:
haemophilia / laboratory assays / prophylaxis regimens / monitoring of efficacySource:
Clinical Laboratory, 2014, 60, 8, 1325-1331Publisher:
- Clin Lab Publ, Heidelberg
Projects:
DOI: 10.7754/Clin.Lab.2013.130817
ISSN: 1433-6510
PubMed: 25185418