Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
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Đunić, IrenaDopsaj, Violeta

Miljić, Predrag
Savić, Nebojša
Milić, Nataša
Mitrović, Mirjana
Suvajdžić-Vuković, Nada
Tomin, Dragica
Elezović, Ivo
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Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 m...onths of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
Keywords:
haemophilia / laboratory assays / prophylaxis regimens / monitoring of efficacySource:
Clinical Laboratory, 2014, 60, 8, 1325-1331Publisher:
- Clin Lab Publ, Heidelberg
Funding / projects:
DOI: 10.7754/Clin.Lab.2013.130817
ISSN: 1433-6510
PubMed: 25185418
WoS: 000342857800009
Scopus: 2-s2.0-84907228464
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PharmacyTY - JOUR AU - Đunić, Irena AU - Dopsaj, Violeta AU - Miljić, Predrag AU - Savić, Nebojša AU - Milić, Nataša AU - Mitrović, Mirjana AU - Suvajdžić-Vuković, Nada AU - Tomin, Dragica AU - Elezović, Ivo PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082 AB - Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis. PB - Clin Lab Publ, Heidelberg T2 - Clinical Laboratory T1 - Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia VL - 60 IS - 8 SP - 1325 EP - 1331 DO - 10.7754/Clin.Lab.2013.130817 ER -
@article{ author = "Đunić, Irena and Dopsaj, Violeta and Miljić, Predrag and Savić, Nebojša and Milić, Nataša and Mitrović, Mirjana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Elezović, Ivo", year = "2014", abstract = "Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.", publisher = "Clin Lab Publ, Heidelberg", journal = "Clinical Laboratory", title = "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia", volume = "60", number = "8", pages = "1325-1331", doi = "10.7754/Clin.Lab.2013.130817" }
Đunić, I., Dopsaj, V., Miljić, P., Savić, N., Milić, N., Mitrović, M., Suvajdžić-Vuković, N., Tomin, D.,& Elezović, I.. (2014). Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory Clin Lab Publ, Heidelberg., 60(8), 1325-1331. https://doi.org/10.7754/Clin.Lab.2013.130817
Đunić I, Dopsaj V, Miljić P, Savić N, Milić N, Mitrović M, Suvajdžić-Vuković N, Tomin D, Elezović I. Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory. 2014;60(8):1325-1331. doi:10.7754/Clin.Lab.2013.130817 .
Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Savić, Nebojša, Milić, Nataša, Mitrović, Mirjana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Elezović, Ivo, "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia" in Clinical Laboratory, 60, no. 8 (2014):1325-1331, https://doi.org/10.7754/Clin.Lab.2013.130817 . .