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Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia

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Authors
Đunić, Irena
Dopsaj, Violeta
Miljić, Predrag
Savić, Nebojša
Milić, Nataša
Mitrović, Mirjana
Suvajdžić-Vuković, Nada
Tomin, Dragica
Elezović, Ivo
Article (Published version)
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Abstract
Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 m...onths of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.

Keywords:
haemophilia / laboratory assays / prophylaxis regimens / monitoring of efficacy
Source:
Clinical Laboratory, 2014, 60, 8, 1325-1331
Publisher:
  • Clin Lab Publ, Heidelberg
Funding / projects:
  • A multidisciplinary study of the role of genetic and acquired autoimmune abnormalities in the onset of systemic manifestations of antiphospholipid syndrome. (RS-175041)

DOI: 10.7754/Clin.Lab.2013.130817

ISSN: 1433-6510

PubMed: 25185418

WoS: 000342857800009

Scopus: 2-s2.0-84907228464
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Miljić, Predrag
AU  - Savić, Nebojša
AU  - Milić, Nataša
AU  - Mitrović, Mirjana
AU  - Suvajdžić-Vuković, Nada
AU  - Tomin, Dragica
AU  - Elezović, Ivo
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
AB  - Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
VL  - 60
IS  - 8
SP  - 1325
EP  - 1331
DO  - 10.7754/Clin.Lab.2013.130817
ER  - 
@article{
author = "Đunić, Irena and Dopsaj, Violeta and Miljić, Predrag and Savić, Nebojša and Milić, Nataša and Mitrović, Mirjana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Elezović, Ivo",
year = "2014",
abstract = "Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia",
volume = "60",
number = "8",
pages = "1325-1331",
doi = "10.7754/Clin.Lab.2013.130817"
}
Đunić, I., Dopsaj, V., Miljić, P., Savić, N., Milić, N., Mitrović, M., Suvajdžić-Vuković, N., Tomin, D.,& Elezović, I.. (2014). Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 60(8), 1325-1331.
https://doi.org/10.7754/Clin.Lab.2013.130817
Đunić I, Dopsaj V, Miljić P, Savić N, Milić N, Mitrović M, Suvajdžić-Vuković N, Tomin D, Elezović I. Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory. 2014;60(8):1325-1331.
doi:10.7754/Clin.Lab.2013.130817 .
Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Savić, Nebojša, Milić, Nataša, Mitrović, Mirjana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Elezović, Ivo, "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia" in Clinical Laboratory, 60, no. 8 (2014):1325-1331,
https://doi.org/10.7754/Clin.Lab.2013.130817 . .

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