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dc.creatorĐunić, Irena
dc.creatorDopsaj, Violeta
dc.creatorMiljić, Predrag
dc.creatorSavić, Nebojša
dc.creatorMilić, Nataša
dc.creatorMitrović, Mirjana
dc.creatorSuvajdžić-Vuković, Nada
dc.creatorTomin, Dragica
dc.creatorElezović, Ivo
dc.date.accessioned2019-09-02T11:38:32Z
dc.date.available2019-09-02T11:38:32Z
dc.date.issued2014
dc.identifier.issn1433-6510
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
dc.description.abstractBackground: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175041/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjecthaemophiliaen
dc.subjectlaboratory assaysen
dc.subjectprophylaxis regimensen
dc.subjectmonitoring of efficacyen
dc.titleComparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophiliaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Небојша; Елезовић, Иво; Ђунић, Ирена; Допсај, Виолета; Миљић, Предраг; Милић, Наташа; Митровић, Мирјана; Сувајджић-Вуковић, Нада; Томин, Драгица;
dc.citation.volume60
dc.citation.issue8
dc.citation.spage1325
dc.citation.epage1331
dc.citation.other60(8): 1325-1331
dc.citation.rankM23
dc.identifier.wos000342857800009
dc.identifier.doi10.7754/Clin.Lab.2013.130817
dc.identifier.pmid25185418
dc.identifier.scopus2-s2.0-84907228464
dc.type.versionpublishedVersion


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