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Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
dc.creator | Đunić, Irena | |
dc.creator | Dopsaj, Violeta | |
dc.creator | Miljić, Predrag | |
dc.creator | Savić, Nebojša | |
dc.creator | Milić, Nataša | |
dc.creator | Mitrović, Mirjana | |
dc.creator | Suvajdžić-Vuković, Nada | |
dc.creator | Tomin, Dragica | |
dc.creator | Elezović, Ivo | |
dc.date.accessioned | 2019-09-02T11:38:32Z | |
dc.date.available | 2019-09-02T11:38:32Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1433-6510 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082 | |
dc.description.abstract | Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis. | en |
dc.publisher | Clin Lab Publ, Heidelberg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175041/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Laboratory | |
dc.subject | haemophilia | en |
dc.subject | laboratory assays | en |
dc.subject | prophylaxis regimens | en |
dc.subject | monitoring of efficacy | en |
dc.title | Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Савић, Небојша; Елезовић, Иво; Ђунић, Ирена; Допсај, Виолета; Миљић, Предраг; Милић, Наташа; Митровић, Мирјана; Сувајджић-Вуковић, Нада; Томин, Драгица; | |
dc.citation.volume | 60 | |
dc.citation.issue | 8 | |
dc.citation.spage | 1325 | |
dc.citation.epage | 1331 | |
dc.citation.other | 60(8): 1325-1331 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000342857800009 | |
dc.identifier.doi | 10.7754/Clin.Lab.2013.130817 | |
dc.identifier.pmid | 25185418 | |
dc.identifier.scopus | 2-s2.0-84907228464 | |
dc.type.version | publishedVersion |
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