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Cytogenetic alterations in peripheral cells of alzheimer's disease patients

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2014
2086.pdf (190.2Kb)
Authors
Plećaš-Solarović, Bosiljka
Đelić, Ninoslav
Bajić, Vladan
Živković, Lada
Potparević, Biljana
Article (Published version)
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Abstract
Alzheimer's disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolis...m, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.

Keywords:
Alzheimer's disease / chromosome instability / peripheral cells
Source:
Genetika, Belgrade, 2014, 46, 1, 315-330
Publisher:
  • Društvo genetičara Srbije, Beograd
Projects:
  • Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)

DOI: 10.2298/GENSR1401315P

ISSN: 0534-0012

WoS: 000338930500031

Scopus: 2-s2.0-84900399583
[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2088
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Plećaš-Solarović, Bosiljka
AU  - Đelić, Ninoslav
AU  - Bajić, Vladan
AU  - Živković, Lada
AU  - Potparević, Biljana
PY  - 2014
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2088
AB  - Alzheimer's disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika, Belgrade
T1  - Cytogenetic alterations in peripheral cells of alzheimer's disease patients
VL  - 46
IS  - 1
SP  - 315
EP  - 330
DO  - 10.2298/GENSR1401315P
ER  - 
@article{
author = "Plećaš-Solarović, Bosiljka and Đelić, Ninoslav and Bajić, Vladan and Živković, Lada and Potparević, Biljana",
year = "2014",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2088",
abstract = "Alzheimer's disease (AD) is the most frequent progressive neurodegenerative disorder in elderly associated with irreversible cognitive impairment and dementia. The vast majority of AD patients are sporadic (SAD) in which the disease develops after age of 65. Despite of century of research, we lack understanding of the SAD etiology and pathogenesis. Several hypotheses try to explain the main causes of brain degeneration in SAD, one of them assuming that genomic instability and the reentry of certain neurons into the incomplete cell cycle may be the pathogenic basis of the disease. Although the brain is the most affected organ in AD, numerous studies showed structural and functional alterations in peripheral tissues, suggesting that AD is a generalized systemic disorder. Diverse changes in peripheral cells from AD patients are described in literature including cell cycle aberration and chromosome instability, alterations in cell viability, proliferation and apoptosis, oxidative metabolism, amyloid precursor protein and amyloid beta protein metabolism, and other cellular processes. The aim of this paper was to summarize and review the results of our investigations and the growing literature data concerning the multiple chromosomal alterations in peripheral cells of AD patients and to consider their possible role in the disease pathogenesis as well as the importance of such investigations.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika, Belgrade",
title = "Cytogenetic alterations in peripheral cells of alzheimer's disease patients",
volume = "46",
number = "1",
pages = "315-330",
doi = "10.2298/GENSR1401315P"
}
Plećaš-Solarović B, Đelić N, Bajić V, Živković L, Potparević B. Cytogenetic alterations in peripheral cells of alzheimer's disease patients. Genetika, Belgrade. 2014;46(1):315-330
Plećaš-Solarović, B., Đelić, N., Bajić, V., Živković, L.,& Potparević, B. (2014). Cytogenetic alterations in peripheral cells of alzheimer's disease patients.
Genetika, BelgradeDruštvo genetičara Srbije, Beograd., 46(1), 315-330.
https://doi.org/10.2298/GENSR1401315P
Plećaš-Solarović Bosiljka, Đelić Ninoslav, Bajić Vladan, Živković Lada, Potparević Biljana, "Cytogenetic alterations in peripheral cells of alzheimer's disease patients" 46, no. 1 (2014):315-330,
https://doi.org/10.2298/GENSR1401315P .

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