Show simple item record

dc.creatorVučićević, Katarina
dc.creatorRakonjac, Zorica
dc.creatorJanković, Borisav Z.
dc.creatorVezmar-Kovačević, Sandra
dc.creatorMiljković, Branislava
dc.creatorProstran, Milica
dc.date.accessioned2019-09-02T11:38:46Z
dc.date.available2019-09-02T11:38:46Z
dc.date.issued2014
dc.identifier.issn1895-1058
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2089
dc.description.abstractGentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I - dosing interval 12 h (n=8), II - 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p lt 0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52 +/- 0.47 l/kg, clearance (CL) 0.055 +/- 0.036 l/hkg and a half-life (t(1/2)) of 6.89 +/- 3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients.en
dc.publisherDe Gruyter Open Ltd, Warsaw
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS//
dc.rightsopenAccess
dc.sourceCentral European Journal of Medicine
dc.subjectNeonatesen
dc.subjectGentamicinen
dc.subjectDosing regimenen
dc.subjectTherapy individualizationen
dc.titleClinical pharmacokinetics in optimal gentamicin dosing regimen in neonatesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПростран, Милица; Јанковић, Борисав З.; Вучићевић, Катарина; Ракоњац, Зорица; Везмар-Ковачевић, Сандра; Миљковић, Бранислава;
dc.citation.volume9
dc.citation.issue3
dc.citation.spage485
dc.citation.epage490
dc.citation.other9(3): 485-490
dc.citation.rankM23
dc.identifier.wos000339337100020
dc.identifier.doi10.2478/s11536-013-0298-7
dc.identifier.scopus2-s2.0-84904035798
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/829/2087.pdf
dc.identifier.rcubconv_3131
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record