FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

In vitro simulation of drug interaction: ciprofloxacin/zinc chloride

Authorized Users Only
2014
Authors
Stojković, Aleksandra
Tajber, Lidia
Đurić, Zorica
Corrigan, Owen I.
Parojčić, Jelena
Article (Published version)
Metadata
Show full item record
Abstract
In vitro dissolution testing has long been used as a tool in drug product development and quality control, however, its potential for drug/food and drug/drug interactions has not yet been filly exploited. Ciprofloxacin absorption in vivo may be reduced when co-administered with different metallic compounds. In the present study, in vitro ciprofloxacin solubility and drug dissolution from tablets were performed in the reactive media containing zinc chloride in order to simulate ciprofloxacin/zinc interaction observed in vivo. The precipitates collected from dissolution vessel and from mixture containing ciprofloxacin-hydrochloride and zinc-chloride were investigated using XRPD, TGA, DCS, FTIR. Ciprofloxacin-hydrochloride solubility and drug dissolution from tablet were reduced in aqueous media containing increasing amounts of zinc-chloride. Complex with probable chemical structure kin [cfH(2)](2)center dot[ZnCl4]center dot 2H(2)O was generated in the presence of high concentrations of c...iprofloxacin-hydrochloride and zinc-chloride, indicating that small volume dissolution experiments can be useful in biopharmaceutical characterisation of drug interaction studies.

Keywords:
Drug interaction / Dissolution / Solubility / Characterisation of the precipitates / Ciprofloxacin
Source:
Journal of Drug Delivery Science and Technology, 2014, 24, 2, 229-233
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/S1773-2247(14)50037-8

ISSN: 1773-2247

WoS: 000339928800017

Scopus: 2-s2.0-84899495324
[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2097
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB