Show simple item record

dc.creatorStojković, Aleksandra
dc.creatorTajber, Lidia
dc.creatorĐurić, Zorica
dc.creatorCorrigan, Owen I.
dc.creatorParojčić, Jelena
dc.date.accessioned2019-09-02T11:38:56Z
dc.date.available2019-09-02T11:38:56Z
dc.date.issued2014
dc.identifier.issn1773-2247
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2097
dc.description.abstractIn vitro dissolution testing has long been used as a tool in drug product development and quality control, however, its potential for drug/food and drug/drug interactions has not yet been filly exploited. Ciprofloxacin absorption in vivo may be reduced when co-administered with different metallic compounds. In the present study, in vitro ciprofloxacin solubility and drug dissolution from tablets were performed in the reactive media containing zinc chloride in order to simulate ciprofloxacin/zinc interaction observed in vivo. The precipitates collected from dissolution vessel and from mixture containing ciprofloxacin-hydrochloride and zinc-chloride were investigated using XRPD, TGA, DCS, FTIR. Ciprofloxacin-hydrochloride solubility and drug dissolution from tablet were reduced in aqueous media containing increasing amounts of zinc-chloride. Complex with probable chemical structure kin [cfH(2)](2)center dot[ZnCl4]center dot 2H(2)O was generated in the presence of high concentrations of ciprofloxacin-hydrochloride and zinc-chloride, indicating that small volume dissolution experiments can be useful in biopharmaceutical characterisation of drug interaction studies.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.subjectDrug interactionen
dc.subjectDissolutionen
dc.subjectSolubilityen
dc.subjectCharacterisation of the precipitatesen
dc.subjectCiprofloxacinen
dc.titleIn vitro simulation of drug interaction: ciprofloxacin/zinc chlorideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦорриган, Оwен И.; Тајбер, Лидиа; Паројчић, Јелена; Стојковић, Aлександра; Ђурић, Зорица;
dc.citation.volume24
dc.citation.issue2
dc.citation.spage229
dc.citation.epage233
dc.citation.other24(2): 229-233
dc.citation.rankM23
dc.identifier.wos000339928800017
dc.identifier.doi10.1016/S1773-2247(14)50037-8
dc.identifier.scopus2-s2.0-84899495324
dc.identifier.rcubconv_3135
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record