Substituted proline derivatives as organocatalysts in the Michael reaction
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Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %.
Keywords:Michael reaction / organocatalysis / proline derivatives
Source:Journal of the Serbian Chemical Society, 2014, 79, 7, 767-778
- Srpsko hemijsko društvo, Beograd