Substituted proline derivatives as organocatalysts in the Michael reaction
2014
Authors
Jovanović, PredragRanđelović, Jelena
Ivković, Branka
Suteu, Cristina
Tokić-Vujošević, Zorana
Savić, Vladimir
Article (Published version)
Metadata
Show full item recordAbstract
Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %.
Keywords:
Michael reaction / organocatalysis / proline derivativesSource:
Journal of the Serbian Chemical Society, 2014, 79, 7, 767-778Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors (RS-MESTD-Basic Research (BR or ON)-172009)
DOI: 10.2298/JSC131015002J
ISSN: 0352-5139
WoS: 000339931600002
Scopus: 2-s2.0-84940265994
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Institution/Community
PharmacyTY - JOUR AU - Jovanović, Predrag AU - Ranđelović, Jelena AU - Ivković, Branka AU - Suteu, Cristina AU - Tokić-Vujošević, Zorana AU - Savić, Vladimir PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2098 AB - Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Substituted proline derivatives as organocatalysts in the Michael reaction VL - 79 IS - 7 SP - 767 EP - 778 DO - 10.2298/JSC131015002J ER -
@article{ author = "Jovanović, Predrag and Ranđelović, Jelena and Ivković, Branka and Suteu, Cristina and Tokić-Vujošević, Zorana and Savić, Vladimir", year = "2014", abstract = "Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Substituted proline derivatives as organocatalysts in the Michael reaction", volume = "79", number = "7", pages = "767-778", doi = "10.2298/JSC131015002J" }
Jovanović, P., Ranđelović, J., Ivković, B., Suteu, C., Tokić-Vujošević, Z.,& Savić, V.. (2014). Substituted proline derivatives as organocatalysts in the Michael reaction. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 79(7), 767-778. https://doi.org/10.2298/JSC131015002J
Jovanović P, Ranđelović J, Ivković B, Suteu C, Tokić-Vujošević Z, Savić V. Substituted proline derivatives as organocatalysts in the Michael reaction. in Journal of the Serbian Chemical Society. 2014;79(7):767-778. doi:10.2298/JSC131015002J .
Jovanović, Predrag, Ranđelović, Jelena, Ivković, Branka, Suteu, Cristina, Tokić-Vujošević, Zorana, Savić, Vladimir, "Substituted proline derivatives as organocatalysts in the Michael reaction" in Journal of the Serbian Chemical Society, 79, no. 7 (2014):767-778, https://doi.org/10.2298/JSC131015002J . .