FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results

Authorized Users Only
2014
Authors
Milinković, Neda
Ignjatović, Svetlana
Žarković, Miloš
Jovičić, Snežana
Radosavljević, Branimir
Singh, Sandra
Majkić-Singh, Nada
Article (Published version)
Metadata
Show full item record
Abstract
Objectives. Defining adequate reference limits (RLs) for thyroid hormones is an important task for support monitoring and the treatment of subclinical thyroid disease. We determined whether there are age-related RLs for thyroid parameters in male and female outpatients free of overt thyroid disease. Design. We analyzed 22,860 results (11,440 male and 11,420 female outpatients above the age of 18) for thyrotropin (TSH), free thyroxine (fT4) and total triiodothyronine (T3) that were stored in our laboratory information system between 2008 and 2011. We calculated the 2.5th and 97.5th centiles for the analyzed thyroid parameters. Results. Our results indicate higher TSH levels with ageing, with a significant difference (p lt 0.05) between the 97.5th centiles for males and females older than 70 (5.07 mIU/L and 4.10 mIU/L), but also a significant difference between male and female fT4 from 31 to 40 and from 41 to 50 years old (18.4 vs 14.9 pmol/L and 19.0 vs 15.9 pmol/L, p lt 0.05), resp...ectively. Overall indirect estimates of the 97.5th centiles for TSH for males and females were not significantly different and were below the generally recommended upper limit (4.01 mIU/L and 4.20 mIU/L, respectively). In addition, we found no statistically signifi cant change in mean T3 values in the analyzed population. Conclusions. This cross-sectional study indicates change in TSH and fT4 levels with ageing and gender-related upper limits. This suggests that by using indirect estimation a laboratory could provide clinicians with more accurate gender- and age-specific RLs for thyroid parameters.

Keywords:
Reference limits / subclinical thyroid disease / thyroid parameters / TSH
Source:
Scandinavian Journal of Clinical and Laboratory Investigation, 2014, 74, 5, 378-384
Publisher:
  • Taylor & Francis Ltd, Abingdon
Funding / projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.3109/00365513.2014.898324

ISSN: 0036-5513

PubMed: 24684474

WoS: 000340429200002

Scopus: 2-s2.0-84906232310
[ Google Scholar ]
19
16
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2099
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Milinković, Neda
AU  - Ignjatović, Svetlana
AU  - Žarković, Miloš
AU  - Jovičić, Snežana
AU  - Radosavljević, Branimir
AU  - Singh, Sandra
AU  - Majkić-Singh, Nada
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2099
AB  - Objectives. Defining adequate reference limits (RLs) for thyroid hormones is an important task for support monitoring and the treatment of subclinical thyroid disease. We determined whether there are age-related RLs for thyroid parameters in male and female outpatients free of overt thyroid disease. Design. We analyzed 22,860 results (11,440 male and 11,420 female outpatients above the age of 18) for thyrotropin (TSH), free thyroxine (fT4) and total triiodothyronine (T3) that were stored in our laboratory information system between 2008 and 2011. We calculated the 2.5th and 97.5th centiles for the analyzed thyroid parameters. Results. Our results indicate higher TSH levels with ageing, with a significant difference (p  lt  0.05) between the 97.5th centiles for males and females older than 70 (5.07 mIU/L and 4.10 mIU/L), but also a significant difference between male and female fT4 from 31 to 40 and from 41 to 50 years old (18.4 vs 14.9 pmol/L and 19.0 vs 15.9 pmol/L, p  lt  0.05), respectively. Overall indirect estimates of the 97.5th centiles for TSH for males and females were not significantly different and were below the generally recommended upper limit (4.01 mIU/L and 4.20 mIU/L, respectively). In addition, we found no statistically signifi cant change in mean T3 values in the analyzed population. Conclusions. This cross-sectional study indicates change in TSH and fT4 levels with ageing and gender-related upper limits. This suggests that by using indirect estimation a laboratory could provide clinicians with more accurate gender- and age-specific RLs for thyroid parameters.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results
VL  - 74
IS  - 5
SP  - 378
EP  - 384
DO  - 10.3109/00365513.2014.898324
ER  - 
@article{
author = "Milinković, Neda and Ignjatović, Svetlana and Žarković, Miloš and Jovičić, Snežana and Radosavljević, Branimir and Singh, Sandra and Majkić-Singh, Nada",
year = "2014",
abstract = "Objectives. Defining adequate reference limits (RLs) for thyroid hormones is an important task for support monitoring and the treatment of subclinical thyroid disease. We determined whether there are age-related RLs for thyroid parameters in male and female outpatients free of overt thyroid disease. Design. We analyzed 22,860 results (11,440 male and 11,420 female outpatients above the age of 18) for thyrotropin (TSH), free thyroxine (fT4) and total triiodothyronine (T3) that were stored in our laboratory information system between 2008 and 2011. We calculated the 2.5th and 97.5th centiles for the analyzed thyroid parameters. Results. Our results indicate higher TSH levels with ageing, with a significant difference (p  lt  0.05) between the 97.5th centiles for males and females older than 70 (5.07 mIU/L and 4.10 mIU/L), but also a significant difference between male and female fT4 from 31 to 40 and from 41 to 50 years old (18.4 vs 14.9 pmol/L and 19.0 vs 15.9 pmol/L, p  lt  0.05), respectively. Overall indirect estimates of the 97.5th centiles for TSH for males and females were not significantly different and were below the generally recommended upper limit (4.01 mIU/L and 4.20 mIU/L, respectively). In addition, we found no statistically signifi cant change in mean T3 values in the analyzed population. Conclusions. This cross-sectional study indicates change in TSH and fT4 levels with ageing and gender-related upper limits. This suggests that by using indirect estimation a laboratory could provide clinicians with more accurate gender- and age-specific RLs for thyroid parameters.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results",
volume = "74",
number = "5",
pages = "378-384",
doi = "10.3109/00365513.2014.898324"
}
Milinković, N., Ignjatović, S., Žarković, M., Jovičić, S., Radosavljević, B., Singh, S.,& Majkić-Singh, N.. (2014). Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 74(5), 378-384.
https://doi.org/10.3109/00365513.2014.898324
Milinković N, Ignjatović S, Žarković M, Jovičić S, Radosavljević B, Singh S, Majkić-Singh N. Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(5):378-384.
doi:10.3109/00365513.2014.898324 .
Milinković, Neda, Ignjatović, Svetlana, Žarković, Miloš, Jovičić, Snežana, Radosavljević, Branimir, Singh, Sandra, Majkić-Singh, Nada, "Indirect estimation of age-related reference limits of thyroid parameters: A cross-sectional study of outpatients' results" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 5 (2014):378-384,
https://doi.org/10.3109/00365513.2014.898324 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB