The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma

2014
Authors
Đurđević, Predrag
Jakovljević, Ivan
Joksović, Ljubinka
Ivanović, Nevena

Jelikić-Stankov, Milena
Article (Published version)
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The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones (FQs) moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric (310 K, 0.15 mol/L NaCl), spectrophotometric, spectrofluorimetric, ESI-MS and H-1-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight (LMW) plasma complex (Cu(Cis) His) is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: (Ni(His)(2) and Zn(Cys) Cit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, Ni(His)(2), even at a concentration level of 3 x 10(-5) mol/L. The same effect is s...een on the main zinc complex, Zn(Cys) Cit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions.
Keywords:
copper / nickel / zinc / fluoroquinolones / complexes / biospeciation / blood plasma / computer simulationSource:
Molecules, 2014, 19, 8, 12194-12223Publisher:
- MDPI, Basel
Funding / projects:
DOI: 10.3390/molecules190812194
ISSN: 1420-3049
PubMed: 25123186
WoS: 000341502600083
Scopus: 2-s2.0-84906658364
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PharmacyTY - JOUR AU - Đurđević, Predrag AU - Jakovljević, Ivan AU - Joksović, Ljubinka AU - Ivanović, Nevena AU - Jelikić-Stankov, Milena PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2104 AB - The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones (FQs) moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric (310 K, 0.15 mol/L NaCl), spectrophotometric, spectrofluorimetric, ESI-MS and H-1-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight (LMW) plasma complex (Cu(Cis) His) is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: (Ni(His)(2) and Zn(Cys) Cit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, Ni(His)(2), even at a concentration level of 3 x 10(-5) mol/L. The same effect is seen on the main zinc complex, Zn(Cys) Cit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions. PB - MDPI, Basel T2 - Molecules T1 - The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma VL - 19 IS - 8 SP - 12194 EP - 12223 DO - 10.3390/molecules190812194 ER -
@article{ author = "Đurđević, Predrag and Jakovljević, Ivan and Joksović, Ljubinka and Ivanović, Nevena and Jelikić-Stankov, Milena", year = "2014", abstract = "The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones (FQs) moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric (310 K, 0.15 mol/L NaCl), spectrophotometric, spectrofluorimetric, ESI-MS and H-1-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight (LMW) plasma complex (Cu(Cis) His) is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: (Ni(His)(2) and Zn(Cys) Cit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, Ni(His)(2), even at a concentration level of 3 x 10(-5) mol/L. The same effect is seen on the main zinc complex, Zn(Cys) Cit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions.", publisher = "MDPI, Basel", journal = "Molecules", title = "The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma", volume = "19", number = "8", pages = "12194-12223", doi = "10.3390/molecules190812194" }
Đurđević, P., Jakovljević, I., Joksović, L., Ivanović, N.,& Jelikić-Stankov, M.. (2014). The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma. in Molecules MDPI, Basel., 19(8), 12194-12223. https://doi.org/10.3390/molecules190812194
Đurđević P, Jakovljević I, Joksović L, Ivanović N, Jelikić-Stankov M. The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma. in Molecules. 2014;19(8):12194-12223. doi:10.3390/molecules190812194 .
Đurđević, Predrag, Jakovljević, Ivan, Joksović, Ljubinka, Ivanović, Nevena, Jelikić-Stankov, Milena, "The Effect of Some Fluoroquinolone Family Members on Biospeciation of Copper(II), Nickel(II) and Zinc(II) Ions in Human Plasma" in Molecules, 19, no. 8 (2014):12194-12223, https://doi.org/10.3390/molecules190812194 . .