How does stress possibly affect cardiac remodeling?
Samo za registrovane korisnike
2014
Autori
Popović, DejanaPlećaš-Solarović, Bosiljka
Pešić, Vesna
Petrović, Milan
Vujisić-Tesić, Bosiljka
Popović, Bojana
Ignjatović, Svetlana
Ristić, Arsen
Damjanović, Svetozar S.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol i...ncreased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p lt 0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.
Ključne reči:
Stress / Adrenocorticotropic hormone / Cortisol / Adrenocorticotropic hormone receptor / polymorphism / Left ventricular remodelingIzvor:
Peptides, 2014, 57, 20-30Izdavač:
- Elsevier Science Inc, New York
Finansiranje / projekti:
- Biomarkeri oštećenja i disfunkcije organa (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.1016/j.peptides.2014.04.006
ISSN: 0196-9781
PubMed: 24751938
WoS: 000338713900004
Scopus: 2-s2.0-84900541761
Institucija/grupa
PharmacyTY - JOUR AU - Popović, Dejana AU - Plećaš-Solarović, Bosiljka AU - Pešić, Vesna AU - Petrović, Milan AU - Vujisić-Tesić, Bosiljka AU - Popović, Bojana AU - Ignjatović, Svetlana AU - Ristić, Arsen AU - Damjanović, Svetozar S. PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2105 AB - This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p lt 0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling. PB - Elsevier Science Inc, New York T2 - Peptides T1 - How does stress possibly affect cardiac remodeling? VL - 57 SP - 20 EP - 30 DO - 10.1016/j.peptides.2014.04.006 ER -
@article{ author = "Popović, Dejana and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Petrović, Milan and Vujisić-Tesić, Bosiljka and Popović, Bojana and Ignjatović, Svetlana and Ristić, Arsen and Damjanović, Svetozar S.", year = "2014", abstract = "This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p lt 0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.", publisher = "Elsevier Science Inc, New York", journal = "Peptides", title = "How does stress possibly affect cardiac remodeling?", volume = "57", pages = "20-30", doi = "10.1016/j.peptides.2014.04.006" }
Popović, D., Plećaš-Solarović, B., Pešić, V., Petrović, M., Vujisić-Tesić, B., Popović, B., Ignjatović, S., Ristić, A.,& Damjanović, S. S.. (2014). How does stress possibly affect cardiac remodeling?. in Peptides Elsevier Science Inc, New York., 57, 20-30. https://doi.org/10.1016/j.peptides.2014.04.006
Popović D, Plećaš-Solarović B, Pešić V, Petrović M, Vujisić-Tesić B, Popović B, Ignjatović S, Ristić A, Damjanović SS. How does stress possibly affect cardiac remodeling?. in Peptides. 2014;57:20-30. doi:10.1016/j.peptides.2014.04.006 .
Popović, Dejana, Plećaš-Solarović, Bosiljka, Pešić, Vesna, Petrović, Milan, Vujisić-Tesić, Bosiljka, Popović, Bojana, Ignjatović, Svetlana, Ristić, Arsen, Damjanović, Svetozar S., "How does stress possibly affect cardiac remodeling?" in Peptides, 57 (2014):20-30, https://doi.org/10.1016/j.peptides.2014.04.006 . .