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dc.creatorPopović, Dejana
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPešić, Vesna
dc.creatorPetrović, Milan
dc.creatorVujisić-Tesić, Bosiljka
dc.creatorPopović, Bojana
dc.creatorIgnjatović, Svetlana
dc.creatorRistić, Arsen
dc.creatorDamjanović, Svetozar S.
dc.date.accessioned2019-09-02T11:39:08Z
dc.date.available2019-09-02T11:39:08Z
dc.date.issued2014
dc.identifier.issn0196-9781
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2105
dc.description.abstractThis aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p lt 0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourcePeptides
dc.subjectStressen
dc.subjectAdrenocorticotropic hormoneen
dc.subjectCortisolen
dc.subjectAdrenocorticotropic hormone receptoren
dc.subjectpolymorphismen
dc.subjectLeft ventricular remodelingen
dc.titleHow does stress possibly affect cardiac remodeling?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПешић, Весна; Петровић, Милан; Вујисић-Тесић, Босиљка; Поповић, Бојана; Ристић, Aрсен; Дамјановић, Светозар С.; Поповић, Дејана; Игњатовић, Светлана; Плећаш-Соларовић, Босиљка;
dc.citation.volume57
dc.citation.spage20
dc.citation.epage30
dc.citation.other57: 20-30
dc.citation.rankM22
dc.identifier.wos000338713900004
dc.identifier.doi10.1016/j.peptides.2014.04.006
dc.identifier.pmid24751938
dc.identifier.scopus2-s2.0-84900541761
dc.type.versionpublishedVersion


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