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dc.creatorRadivojević, Jelena
dc.creatorMinovska, Gordana
dc.creatorSenerović, Lidija
dc.creatorO'Connor, Kevin
dc.creatorJovanović, Predrag
dc.creatorSavić, Vladimir
dc.creatorTokić-Vujošević, Zorana
dc.creatorNikodinović-Runić, Jasmina
dc.creatorMaslak, Veselin
dc.date.accessioned2019-09-02T11:39:10Z
dc.date.available2019-09-02T11:39:10Z
dc.date.issued2014
dc.identifier.issn2046-2069
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2107
dc.description.abstractSynthesis of gamma-nitroaldehydes from branched chain aldehydes and a range of alpha,beta-unsaturated nitroalkenes was achieved by a whole-cell biocatalytic reaction using 4-oxalocrotonate tautomerase as catalyst. Under mild conditions, cyclic and acyclic branched aldehydes were converted into synthetically valuable quaternary carbon containing gamma-nitroaldehydes. The yields of the desired products were influenced by reaction condition parameters such as organic solvent, temperature and pH. The whole-cell biocatalytic approach to the generation of alpha,alpha-substituted gamma-nitroaldehydes was compared to the organocatalytic approach involving the lithium salt of phenylalanine as a catalyst. As the resulting gamma-nitroaldehydes exhibited moderate antifungal activity and mild in vitro cytotoxicity against human fibroblasts (0.2-0.4 mM) they could further be examined as potentially useful pharmaceutical synthons.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.rightsopenAccess
dc.sourceRussian Journal of Genetics
dc.titleSynthesis of gamma-nitroaldehydes containing quaternary carbon in the alpha-position using a 4-oxalocrotonate tautomerase whole-cell biocatalysten
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractМаслак, Веселин; Јовановић, Предраг; Миновска, Гордана; Сенеровић, Лидија; Савић, Владимир; Радивојевић, Јелена; Токић-Вујошевић, Зорана; О'Цоннор, Кевин; Никодиновић-Рунић, Јасмина;
dc.citation.volume4
dc.citation.issue105
dc.citation.spage60502
dc.citation.epage60510
dc.citation.other4(105): 60502-60510
dc.citation.rankM21
dc.identifier.wos000345655600010
dc.identifier.doi10.1039/c4ra05517a
dc.identifier.scopus2-s2.0-84937196259
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/844/2105.pdf
dc.identifier.rcubconv_3213
dc.type.versionpublishedVersion


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