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dc.creatorCvijić, Sandra
dc.creatorLangguth, Peter
dc.date.accessioned2019-09-02T11:39:14Z
dc.date.available2019-09-02T11:39:14Z
dc.date.issued2014
dc.identifier.issn0142-2782
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2108
dc.description.abstractThe purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyrighten
dc.publisherWiley-Blackwell, Hoboken
dc.relationGerman Academic Exchange Service (DAAD) A/12/85086
dc.rightsrestrictedAccess
dc.sourceBiopharmaceutics & Drug Disposition
dc.subjecttrospiumen
dc.subjectabsorption simulationen
dc.subjectfood effecten
dc.subjectviscosityen
dc.subjectbile saltsen
dc.titleImprovement of trospium-specific absorption models for fasted and fed states in humansen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦвијић, Сандра; Ланггутх, Петер;
dc.citation.volume35
dc.citation.issue9
dc.citation.spage553
dc.citation.epage558
dc.citation.other35(9): 553-558
dc.citation.rankM22
dc.identifier.wos000346582500006
dc.identifier.doi10.1002/bdd.1911
dc.identifier.pmid25044357
dc.identifier.scopus2-s2.0-84919951296
dc.identifier.rcubconv_3220
dc.type.versionpublishedVersion


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