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N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
Извор:
Journal of Medicinal Chemistry, 2014, 57, 24, 10455-10463
TY - JOUR
AU - Bautista-Aguilera, Oscar M.
AU - Samadi, Abdelouahid
AU - Chioua, Mourad
AU - Nikolić, Katarina
AU - Filipić, Slavica
AU - Agbaba, Danica
AU - Soriano, Elena
AU - de Andres, Lucia
AU - Isabel Rodriguez-Franco, Maria
AU - Alcaro, Stefano
AU - Ramsay, Rona R.
AU - Ortuso, Francesco
AU - Yanez, Matilde
AU - Marco-Contelles, Jose
PY - 2014
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2113
AB - On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
PB - Amer Chemical Soc, Washington
T2 - Journal of Medicinal Chemistry
T1 - N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual
VL - 57
IS - 24
SP - 10455
EP - 10463
DO - 10.1021/jm501501a
ER -
@article{
author = "Bautista-Aguilera, Oscar M. and Samadi, Abdelouahid and Chioua, Mourad and Nikolić, Katarina and Filipić, Slavica and Agbaba, Danica and Soriano, Elena and de Andres, Lucia and Isabel Rodriguez-Franco, Maria and Alcaro, Stefano and Ramsay, Rona R. and Ortuso, Francesco and Yanez, Matilde and Marco-Contelles, Jose",
year = "2014",
abstract = "On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual",
volume = "57",
number = "24",
pages = "10455-10463",
doi = "10.1021/jm501501a"
}
Bautista-Aguilera, O. M., Samadi, A., Chioua, M., Nikolić, K., Filipić, S., Agbaba, D., Soriano, E., de Andres, L., Isabel Rodriguez-Franco, M., Alcaro, S., Ramsay, R. R., Ortuso, F., Yanez, M.,& Marco-Contelles, J.. (2014). N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington., 57(24), 10455-10463.
https://doi.org/10.1021/jm501501a
Bautista-Aguilera OM, Samadi A, Chioua M, Nikolić K, Filipić S, Agbaba D, Soriano E, de Andres L, Isabel Rodriguez-Franco M, Alcaro S, Ramsay RR, Ortuso F, Yanez M, Marco-Contelles J. N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual. in Journal of Medicinal Chemistry. 2014;57(24):10455-10463.
doi:10.1021/jm501501a .
Bautista-Aguilera, Oscar M., Samadi, Abdelouahid, Chioua, Mourad, Nikolić, Katarina, Filipić, Slavica, Agbaba, Danica, Soriano, Elena, de Andres, Lucia, Isabel Rodriguez-Franco, Maria, Alcaro, Stefano, Ramsay, Rona R., Ortuso, Francesco, Yanez, Matilde, Marco-Contelles, Jose, "N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual" in Journal of Medicinal Chemistry, 57, no. 24 (2014):10455-10463,
https://doi.org/10.1021/jm501501a . .
