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dc.creatorĆurčić, Marijana
dc.creatorDurgo, Ksenija
dc.creatorKopjar, Nevenka
dc.creatorAncić, Mario
dc.creatorVučinić, Slavica
dc.creatorAntonijević, Biljana
dc.date.accessioned2019-09-02T11:39:45Z
dc.date.available2019-09-02T11:39:45Z
dc.date.issued2014
dc.identifier.issn1382-6689
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2128
dc.description.abstractIn order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water. Cells were treated with single Cd in concentrations of 2.5, 7.5 or 15 mu g Cd/mL (corresponding to 22, 67 or 134 mu M), single BDE-209 in concentrations of 2.5, 5 or 10 mu g BDE209/mL (corresponding to 2.5, 5 or 10 mu M), and their mixtures (design 3 x 3). Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation. Factorial regression models used to identify type of interaction revealed synergism related to mixture citotoxicity and additive interaction for the effect on ROS production. The results from this introductory study could contribute to the issue of possible adverse effects associated with co-exposure and body burden with two persistent environmental pollutants, Cd and BDE-209.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceEnvironmental Toxicology and Pharmacology
dc.subjectCden
dc.subjectBDE-209en
dc.subjectMixtureen
dc.subjectcyto-/genotoxicityen
dc.subjectROSen
dc.subjectInteractionsen
dc.titleCadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effectsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДурго, Ксенија; Ћурчић, Маријана; Копјар, Невенка; Aнцић, Марио; Вучинић, Славица; Aнтонијевић, Биљана;
dc.citation.volume38
dc.citation.issue2
dc.citation.spage663
dc.citation.epage671
dc.citation.other38(2): 663-671
dc.citation.rankM22
dc.identifier.wos000343838300035
dc.identifier.doi10.1016/j.etap.2014.07.021
dc.identifier.pmid25218094
dc.identifier.scopus2-s2.0-84907995708
dc.identifier.rcubconv_3184
dc.type.versionpublishedVersion


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