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dc.creatorStanojević, N
dc.creatorJelić-Ivanović, Zorana
dc.creatorDurović, S
dc.creatorSpasojević-Kalimanovska, Vesna
dc.date.accessioned2019-09-02T10:51:17Z
dc.date.available2019-09-02T10:51:17Z
dc.date.issued1999
dc.identifier.issn0354-3447
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/212
dc.description.abstractTransforming growth factor-beta (TGF-beta) is a cytokine with antiatherogenic propretis. The active form of TGF-beta inhibits the activation of endothelial cells, and acts on vascular smooth muscle cells by inhibiting their migration, dediferentiation and proliferation. Lipoprotein (a) i PAI-1 interfere with plasmin-mediated TGF-beta activation by inhibiting the conversion of plasminogen to plasmin. Genetic polymorphism in the TGF beta(1) gene promoter were shown to be correlated with total TGF-beta concentrations, as measured by ELISA after acetic acid/urea activation. Althought many patients with coronary artery disease (CAD) have total TGF-beta concentration below the detection limit, the ability of total TGF-beta assay in discriminating between patients with CAD and individuals with normal coronary arteries is rather limited. Very significant inverse relationship between the concentration of active TGF-beta and CAD was found in several retrospective studies. Minor overlapping between the values in CAD patients and controls was obtained, demostrating the potential of the active TGF-beta as a new marker of CAD, superior to any of the conventional risk factors.en
dc.publisherDruštvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
dc.rightsrestrictedAccess
dc.sourceJugoslovenska medicinska biohemija
dc.subjectAtherosclerosisen
dc.subjectCoronary diseaseen
dc.subjectTransforming growth factoren
dc.titleThe role of transforming growth factor-beta in identifying patients with coronary artery diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасојевић-Калимановска, Весна; Станојевић, Н; Јелић-Ивановић, Зорана; Дуровић, С;
dc.citation.volume18
dc.citation.issue2-3
dc.citation.spage85
dc.citation.epage89
dc.citation.other18(2-3): 85-89
dc.citation.rankM23
dc.identifier.wos000081375900005
dc.identifier.scopus2-s2.0-0032791487
dc.identifier.rcubconv_1206
dc.type.versionpublishedVersion


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