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The role of transforming growth factor-beta in identifying patients with coronary artery disease
dc.creator | Stanojević, N | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Durović, S | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.date.accessioned | 2019-09-02T10:51:17Z | |
dc.date.available | 2019-09-02T10:51:17Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 0354-3447 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/212 | |
dc.description.abstract | Transforming growth factor-beta (TGF-beta) is a cytokine with antiatherogenic propretis. The active form of TGF-beta inhibits the activation of endothelial cells, and acts on vascular smooth muscle cells by inhibiting their migration, dediferentiation and proliferation. Lipoprotein (a) i PAI-1 interfere with plasmin-mediated TGF-beta activation by inhibiting the conversion of plasminogen to plasmin. Genetic polymorphism in the TGF beta(1) gene promoter were shown to be correlated with total TGF-beta concentrations, as measured by ELISA after acetic acid/urea activation. Althought many patients with coronary artery disease (CAD) have total TGF-beta concentration below the detection limit, the ability of total TGF-beta assay in discriminating between patients with CAD and individuals with normal coronary arteries is rather limited. Very significant inverse relationship between the concentration of active TGF-beta and CAD was found in several retrospective studies. Minor overlapping between the values in CAD patients and controls was obtained, demostrating the potential of the active TGF-beta as a new marker of CAD, superior to any of the conventional risk factors. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd | |
dc.rights | restrictedAccess | |
dc.source | Jugoslovenska medicinska biohemija | |
dc.subject | Atherosclerosis | en |
dc.subject | Coronary disease | en |
dc.subject | Transforming growth factor | en |
dc.title | The role of transforming growth factor-beta in identifying patients with coronary artery disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Спасојевић-Калимановска, Весна; Станојевић, Н; Јелић-Ивановић, Зорана; Дуровић, С; | |
dc.citation.volume | 18 | |
dc.citation.issue | 2-3 | |
dc.citation.spage | 85 | |
dc.citation.epage | 89 | |
dc.citation.other | 18(2-3): 85-89 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000081375900005 | |
dc.identifier.scopus | 2-s2.0-0032791487 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_212 | |
dc.type.version | publishedVersion |
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