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Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes

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2014
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Authors
Tanasković, Slađana
Antonijević-Nikolić, Mirjana
Hollo, Berta Barta
Dražić, Branka
Stanojković, Tatjana
Meszaros-Szecsenyi, Katalin
Vucković, Gordana
Article (Published version)
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Abstract
Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of the...ir antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).

Keywords:
copper(II)complexes / octaazamacrocycle / antiproliferative activity / thermal analysis
Source:
Journal of the Serbian Chemical Society, 2014, 79, 10, 1235-1247
Publisher:
  • Srpsko hemijsko društvo, Beograd
Projects:
  • Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-172014)
  • Biological response modifiers in physiological and pathological conditions (RS-175011)

DOI: 10.2298/JSC140404044T

ISSN: 0352-5139

WoS: 000344444800005

Scopus: 2-s2.0-84920748347
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2131
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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