Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes

2014
Authors
Tanasković, Slađana
Antonijević-Nikolić, Mirjana
Hollo, Berta Barta
Dražić, Branka

Stanojković, Tatjana

Meszaros-Szecsenyi, Katalin
Vucković, Gordana
Article (Published version)
Metadata
Show full item recordAbstract
Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of the...ir antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).
Keywords:
copper(II)complexes / octaazamacrocycle / antiproliferative activity / thermal analysisSource:
Journal of the Serbian Chemical Society, 2014, 79, 10, 1235-1247Publisher:
- Srpsko hemijsko društvo, Beograd
Projects:
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-172014)
- Biological response modifiers in physiological and pathological conditions (RS-175011)
DOI: 10.2298/JSC140404044T
ISSN: 0352-5139