Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes
2014
Autori
Tanasković, SlađanaAntonijević-Nikolić, Mirjana
Hollo, Berta Barta
Dražić, Branka
Stanojković, Tatjana
Meszaros-Szecsenyi, Katalin
Vucković, Gordana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of the...ir antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).
Ključne reči:
copper(II)complexes / octaazamacrocycle / antiproliferative activity / thermal analysisIzvor:
Journal of the Serbian Chemical Society, 2014, 79, 10, 1235-1247Izdavač:
- Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
- Dizajniranje, sinteza, karakterizacija i procena praktične primene koordinacionih i organometalnih jedinjenja (RS-172014)
- Modifikatori biološkog odgovora u fiziološkim i patološkim stanjima (RS-175011)
DOI: 10.2298/JSC140404044T
ISSN: 0352-5139
WoS: 000344444800005
Scopus: 2-s2.0-84920748347
Institucija/grupa
PharmacyTY - JOUR AU - Tanasković, Slađana AU - Antonijević-Nikolić, Mirjana AU - Hollo, Berta Barta AU - Dražić, Branka AU - Stanojković, Tatjana AU - Meszaros-Szecsenyi, Katalin AU - Vucković, Gordana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2131 AB - Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4). PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes VL - 79 IS - 10 SP - 1235 EP - 1247 DO - 10.2298/JSC140404044T ER -
@article{ author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Hollo, Berta Barta and Dražić, Branka and Stanojković, Tatjana and Meszaros-Szecsenyi, Katalin and Vucković, Gordana", year = "2014", abstract = "Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes", volume = "79", number = "10", pages = "1235-1247", doi = "10.2298/JSC140404044T" }
Tanasković, S., Antonijević-Nikolić, M., Hollo, B. B., Dražić, B., Stanojković, T., Meszaros-Szecsenyi, K.,& Vucković, G.. (2014). Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 79(10), 1235-1247. https://doi.org/10.2298/JSC140404044T
Tanasković S, Antonijević-Nikolić M, Hollo BB, Dražić B, Stanojković T, Meszaros-Szecsenyi K, Vucković G. Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society. 2014;79(10):1235-1247. doi:10.2298/JSC140404044T .
Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Hollo, Berta Barta, Dražić, Branka, Stanojković, Tatjana, Meszaros-Szecsenyi, Katalin, Vucković, Gordana, "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes" in Journal of the Serbian Chemical Society, 79, no. 10 (2014):1235-1247, https://doi.org/10.2298/JSC140404044T . .