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dc.creatorTanasković, Slađana
dc.creatorAntonijević-Nikolić, Mirjana
dc.creatorHollo, Berta Barta
dc.creatorDražić, Branka
dc.creatorStanojković, Tatjana
dc.creatorMeszaros-Szecsenyi, Katalin
dc.creatorVucković, Gordana
dc.date.accessioned2019-09-02T11:39:48Z
dc.date.available2019-09-02T11:39:48Z
dc.date.issued2014
dc.identifier.issn0352-5139
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2131
dc.description.abstractSeven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectcopper(II)complexesen
dc.subjectoctaazamacrocycleen
dc.subjectantiproliferative activityen
dc.subjectthermal analysisen
dc.titleCorrelations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractТанасковић, Слађана; Холло, Берта Барта; Вуцковић, Гордана; Aнтонијевић-Николић, Мирјана; Станојковић, Татјана; Месзарос-Сзецсенyи, Каталин; Дражић, Бранка;
dc.citation.volume79
dc.citation.issue10
dc.citation.spage1235
dc.citation.epage1247
dc.citation.other79(10): 1235-1247
dc.citation.rankM23
dc.identifier.wos000344444800005
dc.identifier.doi10.2298/JSC140404044T
dc.identifier.scopus2-s2.0-84920748347
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/860/2129.pdf
dc.identifier.rcubconv_3190
dc.type.versionpublishedVersion


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