The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy

2014
Authors
Ardalić, DanielaStefanović, Aleksandra

Kotur-Stevuljević, Jelena

Vujović, Ana
Spasić, Slavica
Spasojević-Kalimanovska, Vesna

Jelić-Ivanović, Zorana

Mandić-Marković, Vesna
Miković, Željko
Cerović, Nikola
Article (Published version)

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Show full item recordAbstract
Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured throug...h the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p lt 0.05) and PON1 activity was significantly lower (p lt 0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.
Keywords:
pregnancy / oxidative stress / habitual maternal smoking / antioxidative supplementationSource:
Advances in Clinical and Experimental Medicine, 2014, 23, 4, 575-583Publisher:
- Wroclaw Medical Univ, Wroclaw
Projects:
DOI: 10.17219/acem/37226
ISSN: 1899-5276
PubMed: 25166442